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AB164478

Recombinant Human TMPRSS13 protein

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Recombinant Human TMPRSS13 protein is a Human Fragment protein, in the 182 to 279 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

MSP, TMPRSS11, TMPRSS13, Transmembrane protease serine 13, Membrane-type mosaic serine protease, Mosaic serine protease

1 Images
SDS-PAGE - Recombinant Human TMPRSS13 protein (AB164478)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TMPRSS13 protein (AB164478)

ab164478 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9BYE2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" } } }
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Sequence info

[{"sequence":"DGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRY","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":279,"aminoAcidStart":182,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9BYE2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Serine protease (PubMed : 20977675, PubMed : 28710277, PubMed : 34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed : 34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed : 20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity).

Sequence similarities

Belongs to the peptidase S1 family.

Post-translational modifications

The inactive zymogen is post-translationally modified and then trafficked to the cell surface, whereby it undergoes autocatalytic cleavage resulting in an activated form that is released extracellularly.. Phosphorylation is required for localization at the cell surface (PubMed:28710277, PubMed:34562451). Phosphorylation increases following inhibition of protease activity by SPINT2/HAI-2 (PubMed:35796294).. N-glycosylation of Asn-405 and Asn-445 is required for exit from the endoplasmic reticulum and trafficking to the cell surface (PubMed:28710277, PubMed:34562451). Also required for autocleavage of the zymogen, activation and secretion of the mature protein (PubMed:34562451).

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Product protocols

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Target data

Serine protease (PubMed : 20977675, PubMed : 28710277, PubMed : 34562451). Cleaves the proform of PRSS8/prostasin to form the active protein (PubMed : 34562451). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (PubMed : 20977675). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity).
See full target information TMPRSS13
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