Recombinant Human TMPRSS2 protein is a Human Fragment protein, in the 106 to 492 aa range, expressed in Cell free, with >=85% purity and suitable for SDS-PAGE.
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Key facts
- Purity
>=85% SDS-PAGE
- Expression system
Cell free
- Tags
His tag N-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
W K F M G S K C S N S G I E C D S S G T C I N P S N W C D G V S H C P G G E D E N R C V R L Y G P N F I L Q V Y S S Q R K S W H P V C Q D D W N E N Y G R A A C R D M G Y K N N F Y S S Q G I V D D S G S T S F M K L N T S A G N V D I Y K K L Y H S D A C S S K A V V S L R C I A C G V N L N S S R Q S R I V G G E S A L P G A W P W Q V S L H V Q N V H V C G G S I I T P E W I V T A A H C V E K P L N N P W H W T A F A G I L R Q S F M F Y G A G Y Q V E K V I S H P N Y D S K T K N N D I A L M K L Q K P L T F N D L V K P V C L P N P G M M L Q P E Q L C W I S G W G A T E E K G K T S E V L N A A K V L L I E T Q R C N S R Y V Y D N L I T P A M I C A G F L Q G N V D S C Q G D S G G P L V T S K N N I W W L I G D T S W G S G C A K A Y R P G V Y G N V M V F T D W I Y R Q M R A D G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).(Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
Alternative names
Transmembrane protease serine 2, Serine protease 10, TMPRSS2, PRSS10
Recommended products
Recombinant Human TMPRSS2 protein is a Human Fragment protein, in the 106 to 492 aa range, expressed in Cell free, with >=85% purity and suitable for SDS-PAGE.
Alternative names
Transmembrane protease serine 2, Serine protease 10, TMPRSS2, PRSS10
Key facts
- Purity
>=85% SDS-PAGE
- Expression system
Cell free
- Tags
His tag N-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- O15393-1
- Animal free
Yes
- Species
Human
- Concentration
- Storage buffer
pH: 7.4 - 8
Constituents: 6% Trehalose, 0.12% Tris, 0.037% Ethylenediaminetetraacetic acid, disodium, dihydrate
Sequence info
Amino acid sequence
W K F M G S K C S N S G I E C D S S G T C I N P S N W C D G V S H C P G G E D E N R C V R L Y G P N F I L Q V Y S S Q R K S W H P V C Q D D W N E N Y G R A A C R D M G Y K N N F Y S S Q G I V D D S G S T S F M K L N T S A G N V D I Y K K L Y H S D A C S S K A V V S L R C I A C G V N L N S S R Q S R I V G G E S A L P G A W P W Q V S L H V Q N V H V C G G S I I T P E W I V T A A H C V E K P L N N P W H W T A F A G I L R Q S F M F Y G A G Y Q V E K V I S H P N Y D S K T K N N D I A L M K L Q K P L T F N D L V K P V C L P N P G M M L Q P E Q L C W I S G W G A T E E K G K T S E V L N A A K V L L I E T Q R C N S R Y V Y D N L I T P A M I C A G F L Q G N V D S C Q G D S G G P L V T S K N N I W W L I G D T S W G S G C A K A Y R P G V Y G N V M V F T D W I Y R Q M R A D G
- Accession
- Protein length
Fragment
- Predicted molecular weight
46.9 kDa
- Amino acids
106 to 492
- Nature
Recombinant
- Tags
His tag N-Terminus
Specifications
- Form
Lyophilized
General info
- Function
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).
- Sequence similarities
Belongs to the peptidase S1 family.
- Post-translational modifications
Proteolytically processed; by an autocatalytic mechanism.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
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1 product image
SDS-PAGE - Recombinant Human TMPRSS2 protein (ab289762)
SDS-PAGE analysis of ab289762
Downloads
Product protocols
- Visit the general protocols
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