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AB219714

Recombinant human TNFRSF14/HVEM protein (Active)

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Recombinant human TNFRSF14/HVEM protein (Active) is a Human Fragment protein, in the 39 to 202 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for FuncS, SDS-PAGE.

View Alternative Names

CD270, HVEA, HVEM, UNQ329/PRO509, TNFRSF14, Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Tumor necrosis factor receptor-like 2, Herpesvirus entry mediator A, HveA, TR2

3 Images
Functional Studies - Recombinant human TNFRSF14/HVEM protein (Active) (AB219714)
  • FuncS

Unknown

Functional Studies - Recombinant human TNFRSF14/HVEM protein (Active) (AB219714)

Immobilized Human HVEM, His Tag at 0.5 µg/mL (100 µL/well) can bind Human BTLA, Fc Tag with a linear range of 0.078-2.5 µg/mL.

Functional Studies - Recombinant human TNFRSF14/HVEM protein (Active) (AB219714)
  • FuncS

Unknown

Functional Studies - Recombinant human TNFRSF14/HVEM protein (Active) (AB219714)

Immobilized Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin at 2 µg/mL (100 µL/well) can bind Human HVEM, His Tag with a linear range of 0.04-0.6 µg/mL.

SDS-PAGE - Recombinant human TNFRSF14/HVEM protein (Active) (AB219714)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human TNFRSF14/HVEM protein (Active) (AB219714)

SDS-PAGE analysis of reduced ab219714 stained overnight with Coomassie Blue.

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Measured by its binding ability in a functional ELISA. Immobilized ab219714 at 0.5 μg/mL (100 μL/well) can bind Human BTLA, Fc Tag with a linear range of 0.078-2.5 μg/mL.

Accession

Q92956

Animal free

No

Carrier free

Yes

Species

Human

Reconstitution

Reconstitute at 200 µg/mL in water

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>The reducing protein migrates as 33-40 kDa in SDS-PAGE due to glycosylation.</p>" } } }
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Product details

This product was previously labelled as TNFRSF14
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Sequence info

[{"sequence":"LPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPAMGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWV","proteinLength":"Fragment","predictedMolecularWeight":"19.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":202,"aminoAcidStart":39,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q92956","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
True
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Specifications

Form

Lyophilized

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General info

Function

Receptor for four distinct ligands : The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed : 10754304, PubMed : 18193050, PubMed : 23761635, PubMed : 9462508). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed : 19915044, PubMed : 9153189, PubMed : 9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed : 10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed : 23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed : 18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity) (PubMed : 19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (By similarity) (PubMed : 19915044).. (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.. (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.

Sequence similarities

Belongs to the tumor necrosis factor receptor superfamily.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Receptor for four distinct ligands : The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed : 10754304, PubMed : 18193050, PubMed : 23761635, PubMed : 9462508). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed : 19915044, PubMed : 9153189, PubMed : 9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed : 10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed : 23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed : 18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (By similarity) (PubMed : 19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (By similarity) (PubMed : 19915044).. (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.. (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.
See full target information TNFRSF14
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