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AB202190

Recombinant Human TNFSF18/GITRL protein

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Recombinant Human TNFSF18/GITRL protein is a Human Fragment protein, in the 70 to 199 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

AITRL, GITRL, TL6, UNQ149/PRO175, TNFSF18, Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand, Glucocorticoid-induced TNF-related ligand, hGITRL

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SDS-PAGE - Recombinant Human TNFSF18/GITRL protein (AB202190)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TNFSF18/GITRL protein (AB202190)

15% SDS-PAGE analysis of ab202190 (3 μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UNG2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MQLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILIANPQEISLEHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"15.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":199,"aminoAcidStart":70,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UNG2","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

ab202190 was purified using conventional chromatography techniques.

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General info

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed : 23892569). Promotes leukocyte adhesion to endothelial cells (PubMed : 23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).

Sequence similarities

Belongs to the tumor necrosis factor family.

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Product protocols

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Target data

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed : 23892569). Promotes leukocyte adhesion to endothelial cells (PubMed : 23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
See full target information TNFSF18
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