Recombinant Human TNFSF18/GITRL protein (His tag) is a Human Fragment protein, in the 72 to 199 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, FuncS
- Biologically active
- No
Amino acid sequence
Q L E T A K E P C M A K F G P L P S K W Q M A S S E P P C V N K V S D W K L E I L Q N G L Y L I Y G Q V A P N A N Y N D V A P F E V R L Y K N K D M I Q T L T N K S K I Q N V G G T Y E L H V G D T I D L I F N S E H Q V L K N N T Y W G I I L L A N P Q F I S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes ab216221 is useful for studying protein binding and for screening small molecules and antibodies. |
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Target data
Function
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Alternative names
AITRL, GITRL, TL6, UNQ149/PRO175, TNFSF18, Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand, Glucocorticoid-induced TNF-related ligand, hGITRL
Recommended products
Recombinant Human TNFSF18/GITRL protein (His tag) is a Human Fragment protein, in the 72 to 199 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, FuncS
- Biologically active
- No
- Accession
- Q9UNG2-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.02% Potassium chloride
Sequence info
Amino acid sequence
- Q L E T A K E P C M A K F G P L P S K W Q M A S S E P P C V N K V S D W K L E I L Q N G L Y L I Y G Q V A P N A N Y N D V A P F E V R L Y K N K D M I Q T L T N K S K I Q N V G G T Y E L H V G D T I D L I F N S E H Q V L K N N T Y W G I I L L A N P Q F I S
- Accession
- Q9UNG2
- Protein length
- Fragment
- Predicted molecular weight
- 17.1 kDa
- Amino acids
- 72 to 199
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
- Sequence similarities
Belongs to the tumor necrosis factor family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Storage information
- Avoid freeze / thaw cycle
Notes
Protein may be diluted to ≥ 100 μg/ml in PBS + glycerol and stored at -80°C.
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2 product images
Functional Studies - Recombinant Human TNFSF18/GITRL protein (His tag) (ab216221)
Example of ab216221 binding biotinylated protein.
SDS-PAGE - Recombinant Human TNFSF18/GITRL protein (His tag) (ab216221)
4-20% SDS-PAGE analysis of ab216221 (2. μg, lane 1).
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Product protocols
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