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AB216221

Recombinant Human TNFSF18/GITRL protein (His tag)

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Recombinant Human TNFSF18/GITRL protein (His tag) is a Human Fragment protein, in the 72 to 199 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

AITRL, GITRL, TL6, UNQ149/PRO175, TNFSF18, Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand, Glucocorticoid-induced TNF-related ligand, hGITRL

2 Images
Functional Studies - Recombinant Human TNFSF18/GITRL protein (His tag) (AB216221)
  • FuncS

Supplier Data

Functional Studies - Recombinant Human TNFSF18/GITRL protein (His tag) (AB216221)

Example of ab216221 binding biotinylated protein.

SDS-PAGE - Recombinant Human TNFSF18/GITRL protein (His tag) (AB216221)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TNFSF18/GITRL protein (His tag) (AB216221)

4-20% SDS-PAGE analysis of ab216221 (2. μg, lane 1).

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag N-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

No

Accession

Q9UNG2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>ab216221 is useful for studying protein binding and for screening small molecules and antibodies.</p>" } } }
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Product details

Protein may be diluted to ≥ 100 μg/ml in PBS + glycerol and stored at -80°C.
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Sequence info

[{"sequence":"QLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS","proteinLength":"Fragment","predictedMolecularWeight":"17.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":199,"aminoAcidStart":72,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9UNG2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed : 23892569). Promotes leukocyte adhesion to endothelial cells (PubMed : 23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).

Sequence similarities

Belongs to the tumor necrosis factor family.

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Product protocols

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Target data

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed : 23892569). Promotes leukocyte adhesion to endothelial cells (PubMed : 23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
See full target information TNFSF18
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