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AB271770

Recombinant human Tnk1 protein (Active) (GST N-Terminus)

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Recombinant human Tnk1 protein (Active) (GST N-Terminus) is a Human Fragment protein, in the 106 to 390 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.

View Alternative Names

Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1, TNK1

2 Images
Functional Studies - Recombinant human Tnk1 protein (Active) (GST N-Terminus) (AB271770)
  • FuncS

Supplier Data

Functional Studies - Recombinant human Tnk1 protein (Active) (GST N-Terminus) (AB271770)

Specific activity of ab271770, ≥3.5 pmol/min/μg.

SDS-PAGE - Recombinant human Tnk1 protein (Active) (GST N-Terminus) (AB271770)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human Tnk1 protein (Active) (GST N-Terminus) (AB271770)

SDS-PAGE analysis of ab271770.

Key facts

Purity

>90% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Specific Activity: ≥3.5 pmol/min/μg.

Accession

Q13470

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.28% Glutathione, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRD","proteinLength":"Fragment","predictedMolecularWeight":"57 kDa","actualMolecularWeight":null,"aminoAcidEnd":390,"aminoAcidStart":106,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q13470","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tnk1 also known as Tyrosine kinase non-receptor 1 or ACK1 is a non-receptor tyrosine kinase with a molecular mass of approximately 72 kDa. This protein plays a role in signal transduction processes by phosphorylating various substrates. Tnk1 finds expression in different tissues with higher levels observed in the brain heart and testes. Its expression is vital for cellular communication and signaling cascades affecting a variety of cellular functions.
Biological function summary

Tnk1 is involved in regulatory mechanisms that control cell growth and apoptosis. Tnk1 is not part of a well-defined complex but it interacts with various cellular proteins affected by phosphorylation. It has a role in regulating signal pathways that influence gene expression contributing to cellular responses to external stimuli. The ability of Tnk1 to modulate these processes highlights its importance in maintaining cellular homeostasis.

Pathways

Tnk1 integrates into signaling networks such as the epidermal growth factor receptor (EGFR) pathway and Ras signaling pathway. In these pathways Tnk1 interacts with proteins like Epidermal Growth Factor Receptor (EGFR) and Ras assisting in the transduction of extracellular signals that govern cell proliferation and survival. The activity of Tnk1 within these pathways ensures that cells respond appropriately to environmental cues coordinating complex cellular responses.

Tnk1 has been implicated in various cancers including lung and breast cancer. Abnormal expression or mutations in Tnk1 may lead to deregulated cell proliferation contributing to oncogenesis. Associations with other proteins like EGFR further define its role in cancer progression. Understanding the involvement of Tnk1 in these illnesses can provide insights into potential therapeutic approaches highlighting its relevance in disease mechanisms and treatment strategies.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Post-translational modifications

Autophosphorylated on tyrosine residues.

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Product protocols

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Target data

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
See full target information TNK1
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Product promise

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