Recombinant Human TPST1 protein (His tag C-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

TPST1 contributes to post-translational modification processes by facilitating the transfer of sulfate groups to proteins specifically on tyrosine residues. This modification influences protein-protein interactions and protein stability and occurs as a part of the protein sulfation complex. This complex comprises multiple enzymes working together to enhance the functionality of the target proteins impacting cellular communication and signaling.

Pathways

TPST1 is involved in pathways associated with cell signaling and immune response. TPST1 contributes actively to the chemokine signaling pathway where it regulates the binding and activity of chemokines. This interaction frequently involves the CCR5 receptor an important element in immune responses and HIV infection pathways. Another significant pathway including TPST1 is G-protein coupled receptor signaling where its sulfation activity influences receptor binding and downstream effects.