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AB156339

Recombinant Human TPST2 protein (denatured) (His tag N-Terminus)

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Recombinant Human TPST2 protein (denatured) (His tag N-Terminus) is a Human Fragment protein, in the 26 to 377 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Protein-tyrosine sulfotransferase 2, Tyrosylprotein sulfotransferase 2, TPST-2, TPST2

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SDS-PAGE - Recombinant Human TPST2 protein (denatured) (His tag N-Terminus) (AB156339)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TPST2 protein (denatured) (His tag N-Terminus) (AB156339)

ab156339 at 3 μg analysed by SDS PAGE.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O60704

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSQQVLECRAVLAGLRSPRGAMRPEQEELVMVGTNHVEYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWSKSGREKLRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLSRLFPNSKFLLMVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIEVMYAQCMEVGKEKCLPVYYEQLVLHPRRSLKLILDFLGIAWSDAVLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSKWTGHIPGDVVRDMAQIAPMLAQLGYDPYANPPNYGNPDPFVINNTQRVLKGDYKTPANLKGYFQVNQNSTSSHLGSS","proteinLength":"Fragment","predictedMolecularWeight":"41 kDa","actualMolecularWeight":null,"aminoAcidEnd":377,"aminoAcidStart":26,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O60704","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TPST2 also known as tyrosylprotein sulfotransferase 2 is an enzyme that transfers a sulfate group to the tyrosine residues of proteins. It has an approximate mass of 54 kDa. TPST2 is expressed in various tissues including the pancreas thyroid and lung. The activity of TPST2 is essential for the post-translational modification process which is important for protein function and interaction.
Biological function summary

Tyrosine sulfation by TPST2 enhances protein-protein interactions impacting various cellular processes. TPST2 often forms a part of larger enzyme complexes within the Golgi apparatus facilitating the sulfation of substrates. This post-translational modification is important for modulating the activity and binding affinity of many proteins with consequences on cell signaling and communication.

Pathways

The enzyme TPST2 participates in the sulfation pathway impacting protein function and regulation within cells. It works alongside proteins such as heparan sulfate proteoglycans (HSPGs) in modulating biological processes. Tyrosine sulfation conducted by TPST2 plays a role in the immune response pathway assisting in the regulation of leukocyte adhesion and signaling.

Aberrations in TPST2 expression or function can connect to several conditions. Research has indicated potential links between TPST2 and inflammatory disorders. Disorders like rheumatoid arthritis may show association due to altered sulfation patterns impacting immune cell interactions. TPST2 has also been studied in relation to cancer where modification of cell surface proteins may influence tumor progression and metastasis.
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Specifications

Form

Liquid

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General info

Function

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Sequence similarities

Belongs to the protein sulfotransferase family.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
See full target information TPST2
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