Recombinant human TRAIL protein
- Bioactive
- What is this?
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(1 Publication)
Recombinant human TRAIL protein is a Human Fragment protein, in the 95 to 281 aa range, expressed in Escherichia coli, with >90%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE, WB, FuncS.
View Alternative Names
CD253, APO2L, TRAIL, TNFSF10, Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, TNF-related apoptosis-inducing ligand, Apo-2L, Protein TRAIL
- WB
Lab
Western blot - Recombinant human TRAIL protein (AB157345)
All lanes:
Western blot - Anti-DDDDK tag (Binds to FLAG® tag sequence) antibody [6F7] (<a href='/en-us/products/primary-antibodies/ddddk-tag-binds-to-flag-tag-sequence-antibody-6f7-ab213519'>ab213519</a>) at 1 µg/mL
Lanes 1 and 3:
Western blot - Recombinant human RANKL protein (Active) (<a href='/en-us/products/proteins-peptides/recombinant-human-rankl-protein-active-ab157289'>ab157289</a>) at 0.5 µg
Lanes 2 and 4:
Western blot - Recombinant human RANKL protein (Active) (<a href='/en-us/products/proteins-peptides/recombinant-human-rankl-protein-active-ab157289'>ab157289</a>) at 0.1 µg
Lane 3:
Western blot - Recombinant human TRAIL protein (ab157345) at 0.5 µg
Lane 4:
Western blot - Recombinant human TRAIL protein (ab157345) at 0.1 µg
Secondary
All lanes:
Goat Anti-Rat IgG H&L (IRDye® 800CW ) (<a href='/en-us/products/unavailable/goat-rat-igg-hl-irdye-800cw-ab253031'>ab253031</a>) at 1/20000 dilution
false
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human TRAIL protein (AB157345)
SDS PAGE analysis of ab157345 (1μg).
Complementary Products
Reactivity data
Product details
Note: ab157345 does not significantly induce apoptosis in the absence of an enhancer.
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TRAIL's function extends beyond inducing cell death. It is an important member of the tumor necrosis factor (TNF) superfamily which regulates immune responses and inflammation. TRAIL can form a homotrimeric complex allowing it to bind effectively to death receptors on target cells specifically DR4 and DR5 triggering a series of downstream signaling events. This interaction is significant in modulating immune surveillance and tumor suppression.
Pathways
TRAIL is integral to both intrinsic and extrinsic apoptosis pathways. Through these pathways TRAIL is closely related to FADD and caspase-8 which are important for apoptosis induction. The extrinsic pathway involves binding to TRAIL death receptors leading to DISC formation while the intrinsic pathway involves mitochondrial events mediated by members of the Bcl-2 protein family.
Specifications
Form
Lyophilized
General info
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed : 10549288, PubMed : 26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Sequence similarities
Belongs to the tumor necrosis factor family.
Post-translational modifications
Tyrosine phosphorylated by PKDCC/VLK.
Target data
Publications (1)
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Journal of immunology research 2022:5582811 PubMed35600049
2022
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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