Recombinant Human TRAM1/TRAM protein (GST tag N-Terminus)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human TRAM1/TRAM protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 374 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
TRAM, TRAM1, Translocating chain-associated membrane protein 1, Protein TRAM1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human TRAM1/TRAM protein (GST tag N-Terminus) (AB161660)
ab161660 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TRAM1 interacts with ribosomes and assists in the co-translational translocation of polypeptides across the endoplasmic reticulum membrane. It forms part of the larger translocon complex which includes Sec61 and other associated proteins. These interactions are necessary for accurate protein targeting and membrane integration ensuring newly synthesized proteins reach their intended cellular compartments.
Pathways
TRAM1 is important for protein secretion and membrane protein biosynthesis pathways. It collaborates closely with Sec61 facilitating protein entry into the ER. It also interfaces with the signal recognition particle (SRP) pathway guiding ribosome-bound nascent chains to the ER membrane. These pathways are essential for proper protein folding processing and eventual function impacting cell signaling and homeostasis.
Specifications
Form
Liquid
General info
Function
Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed : 12475939, PubMed : 1315422, PubMed : 32013668, PubMed : 8616892, PubMed : 9506517). Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER (PubMed : 9506517). May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport (PubMed : 32013668). Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane (PubMed : 8616892). Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane (PubMed : 12475939). Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (PubMed : 20430023).. (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells.
Sequence similarities
Belongs to the TRAM family.
Post-translational modifications
N-glycosylated.
Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com