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AB99862

Recombinant Human Translin/TSN protein (Tag Free)

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Recombinant Human Translin/TSN protein (Tag Free) is a Human Full Length protein, in the 1 to 228 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Translin, Component 3 of promoter of RISC, C3PO, TSN

1 Images
SDS-PAGE - Recombinant Human Translin/TSN protein (AB99862)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human Translin/TSN protein (AB99862)

15% SDS-PAGE showing ab99862 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q15631

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Translin
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Sequence info

[{"sequence":"MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACVEK","proteinLength":"Full Length","predictedMolecularWeight":"26.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":228,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q15631","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Translin also known as TSN is a protein involved in various cellular processes. It has a molecular weight of approximately 26 kDa. The protein forms a homomeric octamer that can bind to specific single-stranded DNA and RNA sequences. Translin is expressed in multiple tissues including the brain where it plays a significant role in neuronal functions. Its expression pattern is important for regulating processes related to nucleic acid metabolism.
Biological function summary

Translin interacts with other proteins to form a complex called the translin-associated protein X (TRAX). This complex participates in mRNA transport and localization within cells influencing the stability and translation of specific mRNAs. Translin's activity in these processes is important for normal cellular function and can impact the regulation of genes involved in cell growth and differentiation.

Pathways

Translin is involved in the DNA damage response and RNA transport pathways. Within these pathways it interacts with proteins such as Dicer and Argonaute which are important for RNA interference and small RNA processing. These interactions illustrate the way Translin can modulate gene expression by influencing RNA stability and degradation.

Alterations in Translin function correlate with neurodegenerative diseases and cancer. Abnormalities in its activity or expression have links to disorders such as schizophrenia where it interacts with proteins like DISC1 which is implicated in psychiatric conditions. Understanding the role of Translin in these contexts can provide insights into its potential as a therapeutic target.
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Specifications

Form

Liquid

Additional notes

ab99862 is purified using conventional chromatography techniques.

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General info

Function

DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.

Sequence similarities

Belongs to the translin family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
See full target information Translin
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Product promise

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