Recombinant Human Translin/TSN protein is a Human Full Length protein, in the 1 to 228 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Images
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M S V S E I F V E L Q G F L A A E Q D I R E E I R K V V Q S L E Q T A R E I L T L L Q G V H Q G A G F Q D I P K R C L K A R E H F G T V K T H L T S L K T K F P A E Q Y Y R F H E H W R F V L Q R L V F L A A F V V Y L E T E T L V T R E A V T E I L G I E P D R E K G F H L D V E D Y L S G V L I L A S E L S R L S V N S V T A G D Y S R P L H I S T F I N E L D S G F R L L N L K N D S L R K R Y D G L K Y D V K K V E E V V Y D L S I R G F N K E T A A A C V E K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
Alternative names
Translin, Component 3 of promoter of RISC, C3PO, TSN
Recombinant Human Translin/TSN protein is a Human Full Length protein, in the 1 to 228 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q15631-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M S V S E I F V E L Q G F L A A E Q D I R E E I R K V V Q S L E Q T A R E I L T L L Q G V H Q G A G F Q D I P K R C L K A R E H F G T V K T H L T S L K T K F P A E Q Y Y R F H E H W R F V L Q R L V F L A A F V V Y L E T E T L V T R E A V T E I L G I E P D R E K G F H L D V E D Y L S G V L I L A S E L S R L S V N S V T A G D Y S R P L H I S T F I N E L D S G F R L L N L K N D S L R K R Y D G L K Y D V K K V E E V V Y D L S I R G F N K E T A A A C V E K
- Accession
- Q15631
- Protein length
- Full Length
- Predicted molecular weight
- 26.1 kDa
- Amino acids
- 1 to 228
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
ab99862 is purified using conventional chromatography techniques.
General info
- Function
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
- Sequence similarities
Belongs to the translin family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as Translin
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Translin also known as TSN is a protein involved in various cellular processes. It has a molecular weight of approximately 26 kDa. The protein forms a homomeric octamer that can bind to specific single-stranded DNA and RNA sequences. Translin is expressed in multiple tissues including the brain where it plays a significant role in neuronal functions. Its expression pattern is important for regulating processes related to nucleic acid metabolism.
- Biological function summary
Translin interacts with other proteins to form a complex called the translin-associated protein X (TRAX). This complex participates in mRNA transport and localization within cells influencing the stability and translation of specific mRNAs. Translin's activity in these processes is important for normal cellular function and can impact the regulation of genes involved in cell growth and differentiation.
- Pathways
Translin is involved in the DNA damage response and RNA transport pathways. Within these pathways it interacts with proteins such as Dicer and Argonaute which are important for RNA interference and small RNA processing. These interactions illustrate the way Translin can modulate gene expression by influencing RNA stability and degradation.
- Associated diseases and disorders
Alterations in Translin function correlate with neurodegenerative diseases and cancer. Abnormalities in its activity or expression have links to disorders such as schizophrenia where it interacts with proteins like DISC1 which is implicated in psychiatric conditions. Understanding the role of Translin in these contexts can provide insights into its potential as a therapeutic target.
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1 product image
SDS-PAGE - Recombinant Human Translin/TSN protein (ab99862)
15% SDS-PAGE showing ab99862 (3μg).
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