Recombinant Human TRAP alpha/TRAPA protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRAP alpha also known as TRAPA or SSR1 is a protein with a mass of approximately 34 kDa. It locates within the endoplasmic reticulum (ER) membrane as a subunit of the translocon-associated protein complex. It has a role in maintaining the translocation of proteins across the endoplasmic reticulum membrane. TRAP alpha is widely expressed in various tissues reflecting its significant function in cellular processes.

Biological function summary

This protein serves as an integral component of the translocon complex facilitating protein transport into the ER. The TRAP complex includes several subunits that work together to ensure protein maturation and folding. TRAP alpha is especially essential for proper protein synthesis and quality control. It plays an important part in cellular homeostasis by ensuring that only correctly assembled proteins proceed to subsequent cellular pathways.

Pathways

TRAP alpha integrates into protein targeting and translocation pathways. It closely engages with the Sec61 complex another fundamental protein in translocation processes. TRAP alpha’s role is important in the secretory pathway which directs proteins destined for different organelles or secretion out of the cell. This pathway is interconnected with other cellular processes like the unfolded protein response ensuring cellular adaptation to stress conditions.

TRAP alpha associates with pathologies such as cystic fibrosis due to its involvement in protein processing. Mutations in proteins associated with TRAP alpha like CFTR can disrupt proper protein folding and cause disease. Additionally there are links between TRAP alpha and certain neurodegenerative conditions as defects in protein handling and folding within the ER can lead to cell death. Such associations also involve proteins like amyloid precursor protein underlining the importance of TRAP alpha in cellular health and disease prevention.