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AB163740

Recombinant Human TRAPPC11 protein

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Recombinant Human TRAPPC11 protein is a Human Full Length protein, in the 1 to 739 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C4orf41, TRAPPC11, Trafficking protein particle complex subunit 11

1 Images
SDS-PAGE - Recombinant Human TRAPPC11 protein (AB163740)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TRAPPC11 protein (AB163740)

ab163740 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q7Z392

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSCVSSYAGFDLSDPEKEKVGILAIQLKERNVVHSEIIITLLSNAVAQFKKYKCPRMKSHLMVQMGEEYYYAKDYTKALKLLDYVMCDYRSEGWWTLLTSVLTTALKCSYLMAQLKDYITYSLELLGRASTLKDDQKSRIEKNLINVLMNESPDPEPDCDILAVKTAQKLWADRISLAGSNIFTIGVQDFVPFVQCKAKFHAPSFHVDVPVQFDIYLKADCPHPIRFSKLCVSFNNQEYNQFCVIEEASKANEVLENLTQGKMCLLPGKTRKLLFKFVAKTEDVGKKIEITSVDLALGNETGRCVVLNWQGGGGDAASSQEALQAARSFKRRPKLPDNEVHWDSIIIQASTMIISRVPNISVHLLHEPPALTNEMYCLVVTVQSHEKTQIRDVKLTAGLKPGQDANLTQKTHVTLHGTELCDESYPALLTDIPVGDLHPGEQLEKMLYVRCGTVGSRMFLVYVSYLINTTVEEKEIVCKCHKDETVTIETVFPFDVAVKFVSTKFEHLERVYADIPFLLMTDLLSASPWALTIVSSELQLAPSMTTVDQLESQVDNVILQTGESASECFCLQCPSLGNIEGGVATGHYIISWKRTSAMENIPIITTVITLPHVIVENIPLHVNADLPSFGRVRESLPVKYHLQNKTDLVQDVEISVEPSDAFMFSGLKQIRLRILPGTEQEMLYNFYPLMAGYQQLPSLNINLLRFPNFTNQLLRRFIPTSIFVKPQGRLMDDTSIAAA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":739,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q7Z392","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRAPPC11 also known as Trafficking Protein Particle Complex 11 is a protein with a mass of about 130 kDa. It is found mainly in the Golgi apparatus where it plays an important role in protein trafficking and membrane dynamics. This protein gets expressed in various tissues prominently in cells involved with high levels of secretion and transport. Its function is linked closely to its participation in the trafficking of proteins within the early secretory pathway.
Biological function summary

TRAPPC11 is involved in the transport of vesicles from the endoplasmic reticulum to the Golgi. It is a subunit of a larger multisubunit complex called the transport protein particle (TRAPP) complex. As a component of this complex it helps maintain its stability and function ensuring proper trafficking of cargo proteins.

Pathways

Vesicle transport TRAPPC11 interacts with critical pathways such as the secretory pathway and endosomal sorting. Within these pathways TRAPPC11 collaborates with other proteins such as TRAPPC2 and TRAPPC3 to maintain vesicle tethering and fusion processes. It contributes significantly to the modulation of transport between the endoplasmic reticulum and Golgi apparatus influencing the efficiency of protein transport and distribution.

Disruptions involving TRAPPC11 can lead to abnormal cellular trafficking linked to conditions like congenital muscular dystrophy and intellectual disability. Mutations in this protein have associations with affecting other proteins such as Golgi-related proteins which further highlight its role in cellular organization. Understanding these connections is key in framing TRAPPC11's role in disease pathology providing insights into potential therapeutic approaches.
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Specifications

Form

Liquid

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General info

Function

Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Sequence similarities

Belongs to the TRAPPC11 family.

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Product protocols

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Target data

Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
See full target information TRAPPC11
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