Recombinant Human TRAPPC4 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRAPPC4 also known as trafficking protein particle complex subunit 4 functions as a component of the TRAPP complex which is involved in vesicle-mediated transport processes. This protein has a mass of approximately 33 kilodaltons. TRAPPC4 expression occurs ubiquitously meaning it's found in various tissues throughout the body at different levels. The protein plays an important role in the transport of proteins between Golgi compartments which are important stages in the processing and modification of proteins within the cell.

Biological function summary

TRAPPC4 participates in the assembly and maintenance of the TRAPP complex a multisubunit tethering complex that facilitates the fusion of vesicles with Golgi membranes. This interaction is essential for ensuring proper protein trafficking and maintaining cellular homeostasis. The TRAPP complex also involves other subunits that assist in regulating transport efficiency. Defects in these processes lead to impaired protein sorting and potential disruption of other cellular functions.

Pathways

The function of TRAPPC4 integrates into the ER-to-Golgi transport pathway where it assists in the trafficking of various proteins essential for cellular activities. Additionally TRAPPC4 plays a role in the Golgi-to-ER retrograde transport pathway. Within these pathways proteins such as Bet3 and Bet5 interact with TRAPPC4 to mediate efficient vesicle tethering and fusion events which are critical for normal protein transport and cell viability.

TRAPPC4 has implications in neurodevelopmental disorders and cancer progression. In certain neurodevelopmental disorders disruptions in TRAPPC4 or its associated pathways can lead to aberrant neural cell function. Furthermore altered TRAPPC4 activity has links to cancer aiding processes such as cell proliferation and migration. In cancer TRAPPC4 often interacts with proteins like TRAPPC3 which together may contribute to oncogenic processes within the affected cells.