Recombinant Human TRAPPC4 protein is a Human Full Length protein, in the 1 to 219 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Images
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M A I F S V Y V V N K A G G L I Y Q L D S Y A P R A E A E K T F S Y P L D L L L K L H D E R V L V A F G Q R D G I R V G H A V L A I N G M D V N G R Y T A D G K E V L E Y L G N P A N Y P V S I R F G R P R L T S N E K L M L A S M F H S L F A I G S Q L S P E Q G S S G I E M L E T D T F K L H C Y Q T L T G I K F V V L A D P R Q A G I D S L L R K I Y E I Y S D F A L K N P F Y S L E M P I R C E L F D Q N L K L A L E V A E K A G T F G P G S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024). May play a role in dendrite postsynaptic membrane trafficking (By similarity).
Alternative names
SBDN, CGI-104, HSPC172, PTD009, TRAPPC4, Trafficking protein particle complex subunit 4, Hematopoietic stem/progenitor cell protein 172, Synbindin, TRS23 homolog
Recommended products
Recombinant Human TRAPPC4 protein is a Human Full Length protein, in the 1 to 219 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9Y296-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M A I F S V Y V V N K A G G L I Y Q L D S Y A P R A E A E K T F S Y P L D L L L K L H D E R V L V A F G Q R D G I R V G H A V L A I N G M D V N G R Y T A D G K E V L E Y L G N P A N Y P V S I R F G R P R L T S N E K L M L A S M F H S L F A I G S Q L S P E Q G S S G I E M L E T D T F K L H C Y Q T L T G I K F V V L A D P R Q A G I D S L L R K I Y E I Y S D F A L K N P F Y S L E M P I R C E L F D Q N L K L A L E V A E K A G T F G P G S
- Accession
- Q9Y296
- Protein length
- Full Length
- Predicted molecular weight
- 26.7 kDa
- Amino acids
- 1 to 219
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab136708 is purified using conventional chromatography techniques.
General info
- Function
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024). May play a role in dendrite postsynaptic membrane trafficking (By similarity).
- Sequence similarities
Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TRAPPC4 also known as trafficking protein particle complex subunit 4 functions as a component of the TRAPP complex which is involved in vesicle-mediated transport processes. This protein has a mass of approximately 33 kilodaltons. TRAPPC4 expression occurs ubiquitously meaning it's found in various tissues throughout the body at different levels. The protein plays an important role in the transport of proteins between Golgi compartments which are important stages in the processing and modification of proteins within the cell.
- Biological function summary
TRAPPC4 participates in the assembly and maintenance of the TRAPP complex a multisubunit tethering complex that facilitates the fusion of vesicles with Golgi membranes. This interaction is essential for ensuring proper protein trafficking and maintaining cellular homeostasis. The TRAPP complex also involves other subunits that assist in regulating transport efficiency. Defects in these processes lead to impaired protein sorting and potential disruption of other cellular functions.
- Pathways
The function of TRAPPC4 integrates into the ER-to-Golgi transport pathway where it assists in the trafficking of various proteins essential for cellular activities. Additionally TRAPPC4 plays a role in the Golgi-to-ER retrograde transport pathway. Within these pathways proteins such as Bet3 and Bet5 interact with TRAPPC4 to mediate efficient vesicle tethering and fusion events which are critical for normal protein transport and cell viability.
- Associated diseases and disorders
TRAPPC4 has implications in neurodevelopmental disorders and cancer progression. In certain neurodevelopmental disorders disruptions in TRAPPC4 or its associated pathways can lead to aberrant neural cell function. Furthermore altered TRAPPC4 activity has links to cancer aiding processes such as cell proliferation and migration. In cancer TRAPPC4 often interacts with proteins like TRAPPC3 which together may contribute to oncogenic processes within the affected cells.
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1 product image
SDS-PAGE - Recombinant Human TRAPPC4 protein (ab136708)
15% SDS-PAGE analysis of 3 µg ab136708.
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