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AB137155

Recombinant Human TRAX protein

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Recombinant Human TRAX protein is a Human Full Length protein, in the 1 to 290 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

TRAX, TSNAX, Translin-associated protein X, Translin-associated factor X

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SDS-PAGE - Recombinant Human TRAX protein (AB137155)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TRAX protein (AB137155)

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

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SDS-PAGE - Recombinant Human TRAX protein (AB137155)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TRAX protein (AB137155)

15% SDS-PAGE analysis of ab137155 (3μg)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q99598

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSNKEGSGGFRKRKHDNFPHNQRREGKDVNSSSPVMLAFKSFQQELDARHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEDILTESEIKLDGVRQKIFQVAQELSGEDMHQFHRAITTGLQEYVEAVSFQHFIKTRSLISMDEINKQLIFTTEDNGKENKTPSSDAQDKQFGTWRLRVTPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVSQFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLAKVENACYALKVRGSEIPKHMLADVFSVKTEMIDQEEGIS","proteinLength":"Full Length","predictedMolecularWeight":"35 kDa","actualMolecularWeight":null,"aminoAcidEnd":290,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99598","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein TRAX also known as Translin-associated factor X functions mechanically as an RNA-binding protein. It plays a role in binding to specific RNA sequences and is involved in RNA transport and stability. The protein has an approximate molecular weight of 31 kDa. TRAX is expressed in various tissues including brain testis and hematopoietic tissues indicating its involvement in diverse biological processes.
Biological function summary

TRAX interacts with Translin to form a heteromeric complex that is involved in mRNA regulation. The complex participates in the regulation of neural development and synaptic plasticity by stabilizing mRNA and modulating its translation. TRAX’s involvement in RNA processing suggests it may have implications in cellular growth and response to stress.

Pathways

TRAX participates in the RNA regulatory network including the MAPK signaling pathway. It influences stress responses and cell survival by associating with proteins like Translin. This pathway coordination ensures cells can adapt to environmental changes efficiently important in maintaining neuronal health.

TRAX has links to neurodegenerative diseases and certain cancers. Alterations in TRAX expression or function can contribute to conditions such as schizophrenia. Its interaction with proteins in disease contexts including Translin suggests that misregulation of the TRAX-Translin complex may play a role in the pathology by impairing RNA transport and stability disrupting cellular functions.
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Specifications

Form

Liquid

Additional notes

ab137155 was purified using conventional chromatography.

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General info

Function

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.

Sequence similarities

Belongs to the translin family.

Post-translational modifications

Sumoylated with SUMO1.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
See full target information TSNAX
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Complementary Products

Primary Antibodies

AB181862

Anti-TRAX antibody [EPR13929(B)]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-TRAX antibody [EPR13929(B)] (AB181862)

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  • 0

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