Recombinant Human TRBV5-4 protein is a Full Length protein, in the 1 to 308 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M G P G L L C W A L L C L L G A G S V E T G V T Q S P T H L I K T R G Q Q V T L R C S S Q S G H N T V S W Y Q Q A L G Q G P Q F I F Q Y Y R E E E N G R G N F P P R F S G L Q F P N Y S S E L N V N A L E L D D S A L Y L C A S S I A R E Q F F G P G T R L T V L E D L K N V F P P E V A V F E P S E A E I S H T Q K A T L V C L A T G F Y P D H V E L S W W V N G K E V H S G V S T D P Q P L K E Q P A L N D S R Y C L S S R L R V S A T F W Q N P R N H F R C Q V Q F Y G L S E N D E W T Q D R A K P V T Q I V S A E A W G R A D C G F T S E S Y Q Q G V L S A T I L Y E I L L G K A T L Y A V L V S A L V L M A M V K R K D S R G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Recommended products
Recombinant Human TRBV5-4 protein is a Full Length protein, in the 1 to 308 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Animal free
- No
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M G P G L L C W A L L C L L G A G S V E T G V T Q S P T H L I K T R G Q Q V T L R C S S Q S G H N T V S W Y Q Q A L G Q G P Q F I F Q Y Y R E E E N G R G N F P P R F S G L Q F P N Y S S E L N V N A L E L D D S A L Y L C A S S I A R E Q F F G P G T R L T V L E D L K N V F P P E V A V F E P S E A E I S H T Q K A T L V C L A T G F Y P D H V E L S W W V N G K E V H S G V S T D P Q P L K E Q P A L N D S R Y C L S S R L R V S A T F W Q N P R N H F R C Q V Q F Y G L S E N D E W T Q D R A K P V T Q I V S A E A W G R A D C G F T S E S Y Q Q G V L S A T I L Y E I L L G K A T L Y A V L V S A L V L M A M V K R K D S R G
- Protein length
- Full Length
- Amino acids
- 1 to 308
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The TRBV5-4 also known as T-cell receptor beta variable 5-4 is a part of the T-cell receptor complex. It contributes to the antigen recognition and immune response function. This protein has a predicted molecular weight of around 13 kDa. TRBV5-4 is expressed in T-cells which are an important component of the adaptive immune system. Understanding the mechanical function of TRBV5-4 is important to elucidate how T-cells identify and respond to pathogens or other foreign substances.
- Biological function summary
TRBV5-4 interacts with other segments of the T-cell receptor complex to mediate T-cell specificity and response. It plays a role in recognizing peptide antigens presented by Major Histocompatibility Complex (MHC) molecules on antigen-presenting cells. The process of antigen recognition is fundamental for initiating T-cell-mediated immune responses. By doing so TRBV5-4 contributes to the adaptive immune system's ability to distinguish between self and non-self molecules and mount appropriate immune responses.
- Pathways
The TRBV5-4's involvement is mainly in the T-cell receptor signaling pathway and the immune synapse formation. It serves as an important component in ensuring T-cell activation upon recognition of the antigen-MHC complex. The pathway involves interaction with several proteins including CD3 and ZAP70 which transduce the activation signal inside the T-cell. These interactions are important for successful signal propagation necessary for subsequent immune responses.
- Associated diseases and disorders
Mutations or alterations in TRBV5-4 expression can be associated with immune system-related conditions such as autoimmune diseases and certain types of cancer. For example its aberrant activity might contribute to the pathogenesis of autoimmune disorders by inappropriate T-cell activation. Additionally TRBV5-4 might link with proteins like the MHC molecules in influencing immune escape mechanisms in cancerous cells. Understanding such associations helps in exploring TRBV5-4 as a potential therapeutic target in these disorders.
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1 product image
SDS-PAGE - Recombinant Human TRBV5-4 protein (ab162170)
ab162170 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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