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AB191918

Recombinant Human TREML2 protein

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Recombinant Human TREML2 protein is a Human Fragment protein, in the 19 to 268 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

C6orf76, TLT2, UNQ6268/PRO20473, TREML2, Trem-like transcript 2 protein, TLT-2, Triggering receptor expressed on myeloid cells-like protein 2

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

Q5T2D2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Complementary Products

Primary Antibodies

AB305103

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Proteins & Peptides

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Recombinant Cynomolgus monkey TREM2 protein

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Primary Antibodies

AB272309

Anti-TREM1 antibody [EPR22060-167] - BSA and Azide free (Capture)

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Sandwich ELISA - Anti-TREM1 antibody [EPR22060-167] - BSA and Azide free (Capture) (AB272309)

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Proteins & Peptides

AB105593

Recombinant Human Iba1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Iba1 protein (His tag N-Terminus) (AB105593)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GPSADSVYTKVRLLEGETLSVQCSYKGYKNRVEGKVWCKIRKKKCEPGFARVWVKGPRYLLQDDAQAKVVNITMVALKLQDSGRYWCMRNTSGILYPLMGFQLDVSPAPQSERNIPFTHLDNILKSGTVTTGQAPTSGPDAPFTTGVMVFTPGLITLPRLLASTRPASKTGYSFTATSTTSQGPRRTMGSQTVTASPSNARDSSAGPESISTKSGDLSTRSPTTGLCLTSRSLLNRLPSMPSIRHQDVYSVDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK","proteinLength":"Fragment","predictedMolecularWeight":"54.24 kDa","actualMolecularWeight":null,"aminoAcidEnd":268,"aminoAcidStart":19,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q5T2D2","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
A few weeks
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TREML2 also known as TREM Like Transcript 2 is a transmembrane protein with a molecular mass of approximately 33 kDa. It belongs to the TREM (Triggering Receptor Expressed on Myeloid cells) family and its expression is mainly in the myeloid lineage especially macrophages and monocytes. Researchers have detected TREML2 on the cell surface and it may also be found in certain endothelial cells. TREML2 contains a V-type immunoglobulin-like domain indicating a role in immune response signaling.
Biological function summary

TREML2 influences immune system modulations and inflammatory responses. It operates within the context of the TREM complexes interacting with adapter proteins like DAP12. Through its immunoregulatory functions TREML2 contributes to the modulation of cytokine production influencing the immune reaction to pathogens. It can also interfere with cell activation processes which proposes it has a role in maintaining balance within the immune environment.

Pathways

TREML2 participates in the innate immune response and inflammatory signaling pathways. It closely interacts with the NF-kB pathway which is central to controlling the expression of various inflammatory cytokines. TREML2's signaling is facilitated by its association with DAP12 which acts as a signaling adapter that enables downstream signaling cascades. This activity suggests integration with other TREM family members including TREM2 which share overlapping roles in immune regulation and inflammation.

TREML2 has connections to neurodegenerative diseases and autoimmune disorders. Studies show that alterations in the expression or functioning of TREML2 correlate with Alzheimer's disease progression possibly influencing amyloid beta processing. In autoimmune conditions TREML2 can modulate immune activity providing a link to dysregulated immune responses as seen in diseases like rheumatoid arthritis. Through its involvement in these conditions TREML2 may interact with proteins such as TREM2 and complement components that also play significant roles in these diseases.
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Specifications

Form

Lyophilized

Additional notes

Purity greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

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Product protocols

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Target data

Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
See full target information TREML2
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