Recombinant Human TRF41 protein (GST tag N-Terminus)
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Recombinant Human TRF41 protein (GST tag N-Terminus) is a Human Fragment protein, in the 2 to 110 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
PAPD7, POLS, TRF4, TENT4A, Terminal nucleotidyltransferase 4A, DNA polymerase sigma, LAK-1, Non-canonical poly(A) RNA polymerase PAPD7, PAP-associated domain-containing protein 7, TRAMP-like complex polyadenylate polymerase, Terminal guanylyltransferase, Terminal uridylyltransferase 5, Topoisomerase-related function protein 4-1, TUTase 5, TRF4-1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human TRF41 protein (GST tag N-Terminus) (AB161265)
ab161265 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TRF41 plays an important role in mediating signal transduction related to cell survival apoptosis and immune responses. It associates as part of larger protein complexes that engage in downstream signaling influencing cellular fate and immune functions. In particular TRF41 interacts with other signaling intermediates amplifying or dampening cellular responses which are essential for maintaining homeostasis and effective immune function.
Pathways
TRF41 takes part in both NF-κB and MAPK signaling pathways. In the NF-κB pathway it interacts with proteins such as TRADD and RIPK1 promoting the activation of transcription factors that drive inflammation and immune responses. Similarly in the MAPK pathway TRF41 connects with various MAP kinases influencing gene expression involved in stress responses. These interactions highlight its fundamental role in linking receptor activation to specific biological outcomes.
Specifications
Form
Liquid
General info
Function
Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed : 23376078, PubMed : 30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed : 23376078).
Sequence similarities
Belongs to the DNA polymerase type-B-like family.
Subcellular localisation
Nucleus
Target data
Product promise
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