Recombinant Human TRFP/MED20 protein
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Recombinant Human TRFP/MED20 protein is a Human Full Length protein, in the 1 to 212 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
TRFP, MED20, Mediator of RNA polymerase II transcription subunit 20, Mediator complex subunit 20, TRF-proximal protein homolog, hTRFP
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human TRFP/MED20 protein (AB139245)
15% SDS-PAGE analysis of 3 µg ab139245.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The Mediator complex which includes MED20 as one of its subunits plays a significant role in the initiation of transcription. MED20 forms part of the larger Mediator complex working closely with other subunits to modulate gene expression. By serving as a scaffold it helps stabilize interactions between transcription factors and RNA polymerase II enhancing transcription efficiency. The complex influences cell growth differentiation and response to cellular signals.
Pathways
MED20's presence in the Mediator complex situates it in critical transcription regulation pathways such as the RNA polymerase II transcription initiation pathway. It interacts with proteins like CDK8 and CCNC integral in controlling transcription by regulating Mediator's cyclin-dependent kinase activity. MED20 fosters connections between regulatory proteins and RNA polymerase II affecting transcription-related cellular signaling.
Specifications
Form
Liquid
Additional notes
ab139245 is purified using conventional chromatography techniques.
General info
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Sequence similarities
Belongs to the Mediator complex subunit 20 family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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