Recombinant Human TRIB1 protein
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Recombinant Human TRIB1 protein is a Human Full Length protein, in the 1 to 372 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, WB.
View Alternative Names
C8FW, GIG2, TRB1, TRIB1, Tribbles homolog 1, TRB-1, G-protein-coupled receptor-induced gene 2 protein, SKIP1, GIG-2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human TRIB1 protein (AB186079)
SDS-PAGE of ab186079.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TRIB1 impacts cell signaling and metabolic processes by forming complexes with other proteins. It exerts a regulatory role by binding to E3 ubiquitin ligases influencing the degradation of target proteins. TRIB1 also interacts with transcription factors affecting gene expression. These actions highlight its involvement in maintaining cellular homeostasis by controlling inflammatory responses and metabolic pathways.
Pathways
TRIB1 influences metabolic and signaling pathways by interacting with key regulatory proteins. It plays a significant role within the MAP kinase pathway and the PI3K-AKT pathway. Both pathways are important for cell proliferation survival and metabolism. In these pathways proteins like ATF4 in the MAP kinase pathway and AKT1 in the PI3K-AKT pathway associate with TRIB1 allowing it to exert control over important cellular processes.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed : 27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed : 26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed : 27041596). Binds selectively the recognition sequence of CEBPA (PubMed : 26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed : 15299019, PubMed : 26455797).
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Target data
Complementary Products
Product promise
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