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AB186094

Recombinant Human TRIB2 protein

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(1 Publication)

Recombinant Human TRIB2 protein is a Human Full Length protein, in the 1 to 343 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, WB.

View Alternative Names

TRB2, TRIB2, Tribbles homolog 2, TRB-2

1 Images
SDS-PAGE - Recombinant Human TRIB2 protein (AB186094)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TRIB2 protein (AB186094)

SDS Page analysis of ab186094

Key facts

Purity

>90% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE

applications

Biologically active

No

Accession

Q92519

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEVSDQLVPDVNMEENLDPFFN","proteinLength":"Full Length","predictedMolecularWeight":"64 kDa","actualMolecularWeight":null,"aminoAcidEnd":343,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q92519","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRIB2 also known as Tribbles homolog 2 is a protein involved in various cellular processes. With a molecular weight of approximately 39 kDa TRIB2 acts as a pseudokinase meaning it lacks catalytic activity but can influence other kinases' function. Researchers found TRIB2 expression in several tissues including the liver lung and immune cells. This protein plays a role in regulating cell proliferation differentiation and apoptosis through its interactions with various signaling pathways and molecules.
Biological function summary

TRIB2 influences cell survival and immune responses. It does not operate alone but forms a part of larger protein complexes to exert its effects. By interacting with transcription factors and other signaling molecules TRIB2 modulates gene expression affecting cell destiny. Though it lacks inherent enzymatic activity TRIB2 can serve as a scaffold or adaptor anchoring other molecules together which significantly shapes cellular dynamics.

Pathways

TRIB2 interacts with several key signaling systems that regulate cell behavior. One notable pathway is the MAPK (Mitogen-Activated Protein Kinase) pathway where TRIB2 affects downstream signaling events that are important for cell growth and response to stress. Additionally TRIB2 engages with the PI3K/AKT pathway a critical mediator of cell survival and metabolism. Within these pathways TRIB2 aligns with or modulates proteins such as AKT and ERK further integrating its role in cellular communication networks.

Researchers have linked TRIB2 to cancer and autoimmune conditions. In the context of cancer elevated TRIB2 levels have been observed in certain leukemias and melanoma where it might promote oncogenic pathways via proteins like C/EBPα or NF-κB. In autoimmune disorders aberrant TRIB2 expression can disrupt immune cell function potentially enhancing inflammatory processes. The protein may indirectly cause shifts in immune tolerance suggesting its involvement in diseases such as rheumatoid arthritis.
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Specifications

Form

Liquid

Additional notes

Assessed by densitometry. Affinity purified.

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General info

Function

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
See full target information TRIB2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 12:42 PubMed33414446

2021

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Susu Guo,Yuxin Chen,Yueyue Yang,Xiao Zhang,Lifang Ma,Xiangfei Xue,Yongxia Qiao,Jiayi Wang
View all publications
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