Recombinant Human TRIB2 protein is a Human Full Length protein, in the 1 to 343 aa range, expressed in Baculovirus infected Sf9, with >90% purity and suitable for SDS-PAGE, WB.
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- Cell death & disease 12:422021TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSusu Guo et. al.PubMed 33414446
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, WB
- Biologically active
- No
Amino acid sequence
M N I H R S T P I T I A R Y G R S R N K T Q D F E E L S S I R S A E P S Q S F S P N L G S P S P P E T P N L S H C V S C I G K Y L L L E P L E G D H V F R A V H L H S G E E L V C K V F D I S C Y Q E S L A P C F C L S A H S N I N Q I T E I I L G E T K A Y V F F E R S Y G D M H S F V R T C K K L R E E E A A R L F Y Q I A S A V A H C H D G G L V L R D L K L R K F I F K D E E R T R V K L E S L E D A Y I L R G D D D S L S D K H G C P A Y V S P E I L N T S G S Y S G K A A D V W S L G V M L Y T M L V G R Y P F H D I E P S S L F S K I R R G Q F N I P E T L S P K A K C L I R S I L R R E P S E R L T S Q E I L D H P W F S T D F S V S N S A Y G A K E V S D Q L V P D V N M E E N L D P F F N
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
Alternative names
TRB2, TRIB2, Tribbles homolog 2, TRB-2
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Recombinant Human TRIB2 protein is a Human Full Length protein, in the 1 to 343 aa range, expressed in Baculovirus infected Sf9, with >90% purity and suitable for SDS-PAGE, WB.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, WB
- Biologically active
- No
- Accession
- Q92519-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
Sequence info
Amino acid sequence
- M N I H R S T P I T I A R Y G R S R N K T Q D F E E L S S I R S A E P S Q S F S P N L G S P S P P E T P N L S H C V S C I G K Y L L L E P L E G D H V F R A V H L H S G E E L V C K V F D I S C Y Q E S L A P C F C L S A H S N I N Q I T E I I L G E T K A Y V F F E R S Y G D M H S F V R T C K K L R E E E A A R L F Y Q I A S A V A H C H D G G L V L R D L K L R K F I F K D E E R T R V K L E S L E D A Y I L R G D D D S L S D K H G C P A Y V S P E I L N T S G S Y S G K A A D V W S L G V M L Y T M L V G R Y P F H D I E P S S L F S K I R R G Q F N I P E T L S P K A K C L I R S I L R R E P S E R L T S Q E I L D H P W F S T D F S V S N S A Y G A K E V S D Q L V P D V N M E E N L D P F F N
- Accession
- Q92519
- Protein length
- Full Length
- Predicted molecular weight
- 64 kDa
- Amino acids
- 1 to 343
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
Assessed by densitometry. Affinity purified.
General info
- Function
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
- Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
- Subcellular localisation
- Cytoskeleton
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TRIB2 also known as Tribbles homolog 2 is a protein involved in various cellular processes. With a molecular weight of approximately 39 kDa TRIB2 acts as a pseudokinase meaning it lacks catalytic activity but can influence other kinases' function. Researchers found TRIB2 expression in several tissues including the liver lung and immune cells. This protein plays a role in regulating cell proliferation differentiation and apoptosis through its interactions with various signaling pathways and molecules.
- Biological function summary
TRIB2 influences cell survival and immune responses. It does not operate alone but forms a part of larger protein complexes to exert its effects. By interacting with transcription factors and other signaling molecules TRIB2 modulates gene expression affecting cell destiny. Though it lacks inherent enzymatic activity TRIB2 can serve as a scaffold or adaptor anchoring other molecules together which significantly shapes cellular dynamics.
- Pathways
TRIB2 interacts with several key signaling systems that regulate cell behavior. One notable pathway is the MAPK (Mitogen-Activated Protein Kinase) pathway where TRIB2 affects downstream signaling events that are important for cell growth and response to stress. Additionally TRIB2 engages with the PI3K/AKT pathway a critical mediator of cell survival and metabolism. Within these pathways TRIB2 aligns with or modulates proteins such as AKT and ERK further integrating its role in cellular communication networks.
- Associated diseases and disorders
Researchers have linked TRIB2 to cancer and autoimmune conditions. In the context of cancer elevated TRIB2 levels have been observed in certain leukemias and melanoma where it might promote oncogenic pathways via proteins like C/EBPα or NF-κB. In autoimmune disorders aberrant TRIB2 expression can disrupt immune cell function potentially enhancing inflammatory processes. The protein may indirectly cause shifts in immune tolerance suggesting its involvement in diseases such as rheumatoid arthritis.
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SDS-PAGE - Recombinant Human TRIB2 protein (ab186094)
SDS Page analysis of ab186094
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