Recombinant Human TRIM protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TRIM (Tripartite Motif) family also known as RBCC (Ring finger B-box Coiled-coil) proteins have an E3 ubiquitin ligase domain. This protein family plays a mechanical role in ubiquitination a process marking proteins for degradation. TRIM proteins weigh between 50 to 90 kDa varying among members. Expression occurs in various tissues and cell types reflecting their diverse functions. These proteins multimerize enabling complex formation important for their mechanism of action.

Biological function summary

TRIM proteins influence an array of cellular functions including cell cycle regulation apoptosis and innate immunity. They have roles in transcriptional regulation and autophagy sometimes functioning as part of larger complexes. Some TRIM proteins like TRIM21 enhance cellular responses to viral infections by tagging viral components for degradation. Other TRIM family members participate in neuron function and development.

Pathways

TRIM proteins interface with key biological systems by modulating pathways such as the NF-κB signaling and interferon response. The NF-κB pathway regulates immune responses and inflammation connecting TRIM proteins with other proteins such as NEMO and IKK. TRIM proteins mediate signaling during viral infections and impact the host's antiviral defense mechanisms. TRIM19 also known as PML interacts within pathways impacting apoptosis and tumorigenesis linking with proteins like p53.

Several TRIM proteins are linked to cancers and autoimmune conditions. For instance TRIM13 shows involvement in multiple myeloma while aberrant expression of TRIM21 associates with systemic lupus erythematosus. Malfunctions in TRIM protein pathways may lead to deregulated cellular responses promoting oncogenic transformation or immune system dysfunction. The connection of TRIM family members with proteins like cyclin D1 in cancer highlights their role in disease.