Recombinant human TRIM37/MUL protein (Active)
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Recombinant human TRIM37/MUL protein (Active) is a Human Full Length protein, in the 1 to 964 aa range, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, FuncS.
View Alternative Names
KIAA0898, MUL, POB1, TRIM37, E3 ubiquitin-protein ligase TRIM37, Mulibrey nanism protein, RING-type E3 ubiquitin transferase TRIM37, Tripartite motif-containing protein 37
- FuncS
Supplier Data
Functional Studies - Recombinant human TRIM37/MUL protein (Active) (AB269066)
The specific activity of ab269066 was 16 nmol/min/mg in a ubiquitinating assay using wild-type ubiquitin protein as substrate.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human TRIM37/MUL protein (Active) (AB269066)
SDS-PAGE analysis of ab269066.
Complementary Products
Reagents, Controls & Accessories
AB234592
Prestained Protein Ladder - Extra broad molecular weight (6.5 - 270 kDa)
- 0
- 0
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TRIM37 regulates processes that are important for cell growth and division as well as for maintaining cellular homeostasis. It functions as part of a larger complex involved in the ubiquitin-proteasome pathway which helps to control protein degradation and recycling within the cell. Through its role in ubiquitination TRIM37 modulates the levels of proteins that are critical for controlling cell cycle progression and responding to stress. Additionally TRIM37 is involved in organizing centrosomes structures that play an important role in chromosome segregation during cell division.
Pathways
TRIM37 interacts with cellular pathways controlling autophagy and the DNA damage response. It contributes to autophagy by regulating proteins that control the formation and clearance of autophagosomes such as ULK1. In the DNA damage response TRIM37 modulates repair processes by regulating the stability of proteins like FANCD2 which is involved in the repair of DNA crosslinks. This illustrates how TRIM37 fits into wider networks inside the cell and influences processes important for maintaining genome integrity.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed : 15885686, PubMed : 23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed : 23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression : associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed : 25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472' : monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed : 28724525). Has anti-HIV activity (PubMed : 24317724).
Sequence similarities
Belongs to the TRIM/RBCC family.
Post-translational modifications
Auto-ubiquitinated.
Target data
Product promise
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