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AB180305

Recombinant Human TRIP-Br2 protein (His tag N-Terminus)

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Recombinant Human TRIP-Br2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 314 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

KIAA0127, TRIPBR2, SERTAD2, SERTA domain-containing protein 2, Transcriptional regulator interacting with the PHD-bromodomain 2, TRIP-Br2

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SDS-PAGE - Recombinant Human TRIP-Br2 protein (His tag N-Terminus) (AB180305)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TRIP-Br2 protein (His tag N-Terminus) (AB180305)

15% SDS-PAGE analysis of ab180305 (3 μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q14140

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as SERTAD2.
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLGKGGKRKFDEHEDGLEGKIVSPCDGPSKVSYTLQRQTIFNISLMKLYNHRPLTEPSLQKTVLINNMLRRIQEELKQEGSLRPMFTPSSQPTTEPSDSYREAPPAFSHLASPSSHPCDLGSTTPLEACLTPASLLEDDDDTFCTSQAMQPTAPTKLSPPALLPEKDSFSSALDEIEELCPTSTSTEAATAATDSVKGTSSEAGTQKLDGPQESRADDSKLMDSLPGNFEITTSTGFLTDLTLDDILFADIDTSMYDFDPCTSSSGTASKMAPVSADDLLKTLAPYSSQPVTPSQPFKMDLTELDHIMEVLVGS","proteinLength":"Full Length","predictedMolecularWeight":"36.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":314,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q14140","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TRIP-Br2 also known as thioridazine-responsive protein Br2 serves as a transcriptional cofactor. This protein has a molecular weight of approximately 40 kDa. TRIP-Br2 is expressed in various tissues including adipose tissue pancreas and liver. It modulates several transcriptional processes by interacting with other proteins facilitating cellular functions through these partnerships.
Biological function summary

TRIP-Br2 influences regulatory functions in metabolic tissues. It participates in complexes that manage cellular growth and energy homeostasis. By interacting with transcriptional machinery TRIP-Br2 impacts processes related to cell cycle control and adipogenesis. These actions highlight its relevance in maintaining cellular function and energy balance in organisms.

Pathways

The regulatory role of TRIP-Br2 associates it with important cellular pathways like the insulin signaling pathway and cell cycle regulation. Within these pathways TRIP-Br2 interacts with proteins such as cyclin-dependent kinases (CDKs) highlighting its involvement in cell division and growth. These associations make it an important component in controlling cellular proliferation and metabolism.

TRIP-Br2 is linked to obesity and metabolic syndrome. Researchers have identified its role in adipocyte differentiation and lipid metabolism suggesting its potential impact on these disorders. TRIP-Br2 interacts with proteins like PPARγ and C/EBPα both important regulators in adipogenesis further connecting it to metabolic conditions. Understanding TRIP-Br2's role in these diseases could lead to new therapeutic strategies.
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Specifications

Form

Liquid

Additional notes

ab180305 was purified by using conventional chromatography techniques

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General info

Function

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.

Post-translational modifications

Polyubiquitinated, which promotes proteasomal degradation.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
See full target information SERTAD2
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