Recombinant Human Troponin C protein (Tag Free)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Troponin C often referred to as TnC is a protein that plays a mechanical role in muscle contraction. It is part of the troponin complex weighing approximately 18 kDa. This protein is expressed in cardiac and skeletal muscles where it functions as a calcium-binding component. Troponin C by responding to changes in calcium ion concentration interacts with troponin I and troponin T to regulate the contraction and relaxation cycles of muscle fibers.

Biological function summary

Through its calcium binding ability Troponin C initiates a conformational change in the troponin complex. This action releases the inhibition imposed by tropomyosin on actin filaments thereby allowing myosin heads to interact with actin. As part of the troponin complex Troponin C ensures precise muscle function and is essential for cardiac and skeletal muscle physiology. Its interaction with troponin I and troponin T highlights its regulatory role in muscle contraction.

Pathways

The protein is integral to the muscle contraction pathway and cardiac function. Within these pathways Troponin C's role is connected to the sliding filament model of muscle contraction where it regulates actin-myosin interactions. It works closely with proteins like myosin and its function is tied to multiple signaling pathways like the calcium signaling pathway which further influences muscle contraction and relaxation cycles.

Troponin C is highly significant in the context of cardiovascular diseases and skeletal muscle disorders. Elevated levels of the troponin complex in the bloodstream often indicate conditions such as myocardial infarction. Moreover mutations affecting Troponin C can lead to cardiomyopathies including hypertrophic and dilated cardiomyopathy. Its relation to troponin I and troponin T within these disorders emphasizes the critical nature of protein interactions in maintaining muscle health and identifying disease.