Recombinant Human TSPAN31 protein (Fc Chimera)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TSPAN31 also known as Tetraspanin-31 is a protein that belongs to the tetraspanin family which is known for its role in cell surface receptor interactions. The protein has a molecular mass of around 26 kDa. TSPAN31 contains four transmembrane domains that contribute to its architecture. This protein is expressed in various tissues and cells with significant presence in the spleen heart and kidneys. TSPAN31 functions by facilitating the organization of protein complexes which are important for cellular processes like signal transduction and intercellular communication.

Biological function summary

TSPAN31 operates as a component of the larger tetraspanin web which organizes interactions at the cell membrane level. It influences cell adhesion migration and possibly proliferation playing roles in cellular dynamics. Tetraspanins like TSPAN31 often do not work in isolation but form complexes with integrins growth factor receptors and other membrane proteins. This interaction is essential for coordinating cellular responses to external stimuli regulating communication between cells and their environment which impacts tissue development and immune function.

Pathways

The activity of TSPAN31 is linked to critical cellular pathways involving cell signaling and migration. The protein influences the Wnt signaling pathway which is important for regulating cellular proliferation and differentiation. TSPAN31 also interacts with integrin-linked pathways involving other tetraspanins like CD151 modulating cellular adhesion and movement. These pathways are important for various physiological processes including tissue repair and immune responses.

Aberrations in TSPAN31 expression or function have potential links to cancer and immune system disorders. Overexpression of TSPAN31 has been associated with certain cancers such as ovarian carcinoma where it may contribute to tumor progression through altered cell adhesion and migration. In the realm of immune disorders variants in the expression or regulation of TSPAN31 along with other tetraspanins like CD37 could affect immune cell signaling and function possibly playing a part in autoimmune conditions or inflammation-related disorders.