Recombinant Human TSSC3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TSSC3 also known as Tumor Suppressor Candidate 3 encodes a protein with a molecular weight of approximately 25 kDa. This protein is encoded by a gene located on human chromosome 11. TSSC3 undergoes expression in various tissues with high levels in the placenta and kidney. The protein functions as a pro-apoptotic factor playing a role in promoting apoptosis by influencing mitochondrial membrane potential and cytochrome c release.

Biological function summary

The protein encoded by TSSC3 acts in cellular processes that regulate apoptosis which is a mechanism of programmed cell death essential for maintaining cellular homeostasis. Though not part of a larger protein complex TSSC3 interacts with other mitochondrial proteins to execute its function as an apoptosis promoter. Its role in apoptosis suggests its importance in developmental processes and in the elimination of damaged cells thereby contributing to tissue health.

Pathways

TSSC3 modulates cellular apoptosis pathways including the intrinsic apoptotic pathway. Within these pathways TSSC3 interacts with proteins like BAX and BAK which influence mitochondrial membrane integrity and cytochrome c release. Through these interactions TSSC3 helps regulate the balance between cell survival and death influencing cell fate decisions in response to various stimuli.

TSSC3 has known associations with several cancers including Wilms' tumor and choriocarcinoma due to its tumor suppressor properties. When TSSC3 function is impaired or its expression reduced there is evidence suggesting an increase in tumorigenic activities. The relationship between TSSC3 and the p53 protein an important tumor suppressor further supports its role in cancer as they both influence apoptotic pathways that suppress abnormal cell proliferation.