Recombinant Human TSSK6 protein is a Human Full Length protein, in the 1 to 273 aa range, expressed in Baculovirus infected Sf9, with >75% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >75% Densitometry
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M S G D K L L S E L G Y K L G R T I G E G S Y S K V K V A T S K K Y K G T V A I K V V D R R R A P P D F V N K F L P R E L S I L R G V R H P H I V H V F E F I E V C N G K L Y I V M E A A A T D L L Q A V Q R N G R I P G V Q A R D L F A Q I A G A V R Y L H D H H L V H R D L K C E N V L L S P D E R R V K L T D F G F G R Q A H G Y P D L S T T Y C G S A A Y A S P E V L L G I P Y D P K K Y D V W S M G V V L Y V M V T G C M P F D D S D I A G L P R R Q K R G V L Y P E G L E L S E R C K A L I A E L L Q F S P S A R P S A G Q V A R N C W L R A G D S G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules (PubMed:15870294). May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins (By similarity). Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis (By similarity).
Alternative names
SSTK, FKSG82, TSSK6, Testis-specific serine/threonine-protein kinase 6, TSK-6, TSSK-6, Testis-specific kinase 6, Cancer/testis antigen 72, Serine/threonine-protein kinase SSTK, Small serine/threonine kinase, CT72
Recommended products
Recombinant Human TSSK6 protein is a Human Full Length protein, in the 1 to 273 aa range, expressed in Baculovirus infected Sf9, with >75% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >75% Densitometry
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9BXA6-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
Sequence info
Amino acid sequence
- M S G D K L L S E L G Y K L G R T I G E G S Y S K V K V A T S K K Y K G T V A I K V V D R R R A P P D F V N K F L P R E L S I L R G V R H P H I V H V F E F I E V C N G K L Y I V M E A A A T D L L Q A V Q R N G R I P G V Q A R D L F A Q I A G A V R Y L H D H H L V H R D L K C E N V L L S P D E R R V K L T D F G F G R Q A H G Y P D L S T T Y C G S A A Y A S P E V L L G I P Y D P K K Y D V W S M G V V L Y V M V T G C M P F D D S D I A G L P R R Q K R G V L Y P E G L E L S E R C K A L I A E L L Q F S P S A R P S A G Q V A R N C W L R A G D S G
- Accession
- Q9BXA6
- Protein length
- Full Length
- Predicted molecular weight
- 57 kDa
- Amino acids
- 1 to 273
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
Affinity purified.
General info
- Function
Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules (PubMed:15870294). May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins (By similarity). Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis (By similarity).
- Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
- Post-translational modifications
Autophosphorylated.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The testis-specific serine/threonine-protein kinase 6 (TSSK6) is a kinase enzyme important in the regulation of spermatogenesis. Also known as TSSK-6 or STK22D TSSK6 has a molecular weight of approximately 39 kDa. Primarily expressed in the testis TSSK6 exhibits expression almost exclusively in germ cells which are essential for male fertility. Its kinase activity adds phosphate groups to serine and threonine residues of substrate proteins influencing their activity stability and interactions.
- Biological function summary
TSSK6 contributes to sperm development playing a pivotal role in sperm maturation and function. It participates in the formation of the sperm tail ensuring proper motility and structural integrity. TSSK6 operates as part of kinase complexes that modulate other proteins essential for the assembly of the fibrous sheath an important structure surrounding the axoneme of the sperm tail. This association highlights the requirement of TSSK6 in forming functional sperm cells.
- Pathways
TSSK6 interfaces with the spermatogenesis pathway where it facilitates sequential steps in sperm cell development. It also integrates into the protein phosphorylation pathway interacting with proteins like CSNK2A1 (casein kinase 2 alpha 1) which regulate cellular processes related to sperm motility and viability. The catalytic activity of TSSK6 ensures that phosphorylation events needed for sperm function occur efficiently helping maintain reproductive competence.
- Associated diseases and disorders
TSSK6 shows strong connections to male infertility particularly cases linked to defective sperm motility or morphology. Mutations or expression alterations of TSSK6 can disrupt the phosphorylation cycles essential for the architecture of sperm cells leading to asthenozoospermia a condition characterized by reduced sperm motility. Studies also relate TSSK6 to interactions with the protein HSPA2 (heat shock protein family A member 2) where their association influences protein folding processes necessary for sperm development and function.
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SDS-PAGE - Recombinant Human TSSK6 protein (ab204149)
SDS-PAGE analysis of ab204149.
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