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AB180300

Recombinant Human TSSK6 protein - BSA and Azide free (denatured) (His tag N-Terminus)

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Recombinant Human TSSK6 protein - BSA and Azide free (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 273 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

SSTK, FKSG82, TSSK6, Testis-specific serine/threonine-protein kinase 6, TSK-6, TSSK-6, Testis-specific kinase 6, Cancer/testis antigen 72, Serine/threonine-protein kinase SSTK, Small serine/threonine kinase, CT72

1 Images
SDS-PAGE - Recombinant Human TSSK6 protein - BSA and Azide free (denatured) (His tag N-Terminus) (AB180300)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TSSK6 protein - BSA and Azide free (denatured) (His tag N-Terminus) (AB180300)

15% SDS-PAGE analysis of ab180300 (3μg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BXA6

Animal free

No

Carrier free

Yes

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG","proteinLength":"Full Length","predictedMolecularWeight":"32.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":273,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BXA6","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The testis-specific serine/threonine-protein kinase 6 (TSSK6) is a kinase enzyme important in the regulation of spermatogenesis. Also known as TSSK-6 or STK22D TSSK6 has a molecular weight of approximately 39 kDa. Primarily expressed in the testis TSSK6 exhibits expression almost exclusively in germ cells which are essential for male fertility. Its kinase activity adds phosphate groups to serine and threonine residues of substrate proteins influencing their activity stability and interactions.
Biological function summary

TSSK6 contributes to sperm development playing a pivotal role in sperm maturation and function. It participates in the formation of the sperm tail ensuring proper motility and structural integrity. TSSK6 operates as part of kinase complexes that modulate other proteins essential for the assembly of the fibrous sheath an important structure surrounding the axoneme of the sperm tail. This association highlights the requirement of TSSK6 in forming functional sperm cells.

Pathways

TSSK6 interfaces with the spermatogenesis pathway where it facilitates sequential steps in sperm cell development. It also integrates into the protein phosphorylation pathway interacting with proteins like CSNK2A1 (casein kinase 2 alpha 1) which regulate cellular processes related to sperm motility and viability. The catalytic activity of TSSK6 ensures that phosphorylation events needed for sperm function occur efficiently helping maintain reproductive competence.

TSSK6 shows strong connections to male infertility particularly cases linked to defective sperm motility or morphology. Mutations or expression alterations of TSSK6 can disrupt the phosphorylation cycles essential for the architecture of sperm cells leading to asthenozoospermia a condition characterized by reduced sperm motility. Studies also relate TSSK6 to interactions with the protein HSPA2 (heat shock protein family A member 2) where their association influences protein folding processes necessary for sperm development and function.
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Specifications

Form

Liquid

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General info

Function

Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules (PubMed : 15870294). May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins (By similarity). Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Post-translational modifications

Autophosphorylated.. Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.

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Product protocols

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Target data

Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules (PubMed : 15870294). May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins (By similarity). Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis (By similarity).
See full target information TSSK6
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