Recombinant Human TSTD3 protein is a Human Full Length protein, in the 1 to 97 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M K I E K C G W S E G L T S I K G N C H N F Y T A I S K D V T Y K E L K N L L N S K N I M L I D V R E I W E I L E Y Q K I P E S I N V P L D E V G E A L Q M N P R D F K E K Y N E V K P S K S D S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3, Rhodanese domain-containing protein 3, TSTD3
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Recombinant Human TSTD3 protein is a Human Full Length protein, in the 1 to 97 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- H0UI37-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M K I E K C G W S E G L T S I K G N C H N F Y T A I S K D V T Y K E L K N L L N S K N I M L I D V R E I W E I L E Y Q K I P E S I N V P L D E V G E A L Q M N P R D F K E K Y N E V K P S K S D S
- Accession
- H0UI37
- Protein length
- Full Length
- Predicted molecular weight
- 13.7 kDa
- Amino acids
- 1 to 97
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
purified by using conventional chromatography techniques.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TSTD3 also known as thiosulfate sulfurtransferase-like domain-containing 3 is a protein with a molecular mass around 47 kDa. The protein mainly localizes in the cytoplasm and its expression is detected in various tissues including the liver and heart. TSTD3 is part of a family of enzymes with sulfurtransferase activity. It belongs to the rhodanese homology domain-containing proteins known for transferring sulfur from donor molecules to target molecules facilitating the formation of thiol groups.
- Biological function summary
TSTD3 engages in sulfur metabolism playing a role in the detoxification of cyanide by converting it into less harmful thiocyanate. This protein functions independently rather than as part of a larger complex. It contributes to maintaining cellular homeostasis by scavenging reactive sulfur species and mitigating oxidative damage. Its enzymatic activity assists in preserving cellular redox balance which is central to cell survival and proper function particularly under stress conditions where sulfur metabolism demand increases.
- Pathways
TSTD3 plays a significant role in cyanide detoxification and sulfur metabolism pathways. It works alongside other sulfurtransferases such as TST which also participates in cyanide detoxification. Both pathways ensure that toxic byproducts like hydrogen sulfide and cyanide are efficiently neutralized reducing cellular stress and damage. This activity links TSTD3 closely with cellular response mechanisms to oxidative stress and toxic insults emphasizing its importance in maintaining cellular health.
- Associated diseases and disorders
TSTD3 is particularly relevant in conditions related to oxidative stress and mitochondrial dysfunction like cardiovascular diseases. Aberrant expression or malfunction of TSTD3 can disrupt sulfur metabolism leading to increased oxidative stress and cellular damage which may contribute to the progression of heart-related ailments. Its connection with TST also suggests a possible role in metabolic disorders where detoxification pathways become overwhelmed potentially leading to tissue damage and disease progression.
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1 product image
SDS-PAGE - Recombinant Human TSTD3 protein (ab167916)
15% SDS-PAGE analysis of 3 μg ab167916
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