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AB130015

Recombinant Human TTC1 protein

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Recombinant Human TTC1 protein is a Human Full Length protein, in the 1 to 292 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

TPR1, TTC1, Tetratricopeptide repeat protein 1, TPR repeat protein 1

1 Images
SDS-PAGE - Recombinant Human TTC1 protein (AB130015)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human TTC1 protein (AB130015)

15% SDS-PAGE analysis of 3 μg ab130015.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q99614

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR","proteinLength":"Full Length","predictedMolecularWeight":"36.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":292,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99614","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TTC1 also known as Tetratricopeptide Repeat Domain 1 is a protein that plays a role in various cellular processes. This protein has a molecular mass of approximately 39 kDa. TTC1 is widely expressed in human tissues with notable levels in liver kidney heart and skeletal muscle. TTC1 contains multiple tetratricopeptide repeat (TPR) motifs which suggests its potential involvement in protein-protein interactions assisting in the folding and stabilization of other proteins.
Biological function summary

TTC1 functions as a molecular chaperone involved in the stabilization of the small GTPase RAN an essential component for nuclear-cytoplasmic transport. TTC1 partners with the RAN binding protein pathway forming a complex that supports the physiological dynamics of RAN. Its role in maintaining the integrity of RAN inside the cell further highlights its function in ensuring proper cell division and transport processes.

Pathways

The TTC1 protein is involved in the nuclear transportation and stabilization pathways. It interacts notably with RAN as well as components like RANBP1 in ensuring proper nuclear import and export activities. TTC1's stabilization role of RAN impacts the nucleocytoplasmic transport pathway and the mitotic spindle checkpoint important for accurate chromosome segregation during cell division.

TTC1 is of interest due to its connection to certain cancers and neurodegenerative diseases. Altered expression or mutation of TTC1 can disrupt normal RAN-mediated transport potentially contributing to cancerous growth and progression as it might affect cellular proliferation control. Its relationship with neurodegenerative conditions links to dysregulation of protein transport and cell cycle control with RAN itself as a relevant partner in this context suggesting a broader implication of TTC1 in cellular dysfunction related to these disorders.
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Specifications

Form

Liquid

Additional notes

ab130015 is purified using conventional chromatography.

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General info

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Product protocols

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Target data

See full target information TTC1
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