Recombinant Human TTC32 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TTC32 also known as Tetratricopeptide Repeat Domain 32 is a protein that interacts with other proteins through its tetratricopeptide repeat domains. It has a molecular mass of approximately 41 kDa. The protein exhibits expression in several tissues including the brain testis and ovary indicating its widespread role in various physiological processes. TTC32 can mediate protein-protein interactions facilitating the assembly and function of multiprotein complexes.

Biological function summary

TTC32 plays a role in cellular functions by participating in the organization and stability of protein complexes. It often takes part as a member of protein complexes that contribute to intracellular signaling and structural organization. The protein's ability to bind to specific partners allows it to influence multiple cellular processes impacting cell division differentiation and other essential functions. TTC32's involvement in these complexes allows for adaptability and specificity in cellular responses.

Pathways

TTC32 integrates into relevant biological pathways that involve cell cycle regulation and signal transduction. It associates with the MAPK signaling pathway which is critical for transmitting extracellular signals into appropriate cellular responses. In this pathway TTC32 interacts with proteins such as ERK and JNK which are essential for properly managing cellular growth and stress responses. By engaging in pathways like these TTC32 contributes to maintaining cellular homeostasis and response to environmental changes.

Dysfunction or aberrant expression of TTC32 has been linked to cancer and neurodegenerative diseases. In cancer changes in TTC32 expression affect its interaction with proteins such as p53 altering the regulation of apoptosis and potentially leading to unchecked cell proliferation. Similarly in neurodegenerative diseases TTC32 may interact with proteins related to neuronal signaling pathways impacting nerve cell health and function. Understanding TTC32's role in these diseases could reveal new therapeutic targets and diagnostic markers.