Recombinant Human TTDA protein (His tag N-Terminus)
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Recombinant Human TTDA protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 71 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
C6orf175, TTDA, GTF2H5, General transcription factor IIH subunit 5, General transcription factor IIH polypeptide 5, TFB5 ortholog, TFIIH basal transcription factor complex TTD-A subunit, TFIIH subunit p8
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human TTDA protein (His tag N-Terminus) (AB187616)
15% SDS-PAGE (ab187616 at 3μg)
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This protein plays a role in maintaining genomic integrity by ensuring effective DNA repair. Acting as part of the TFIIH complex TTDA facilitates the recognition and excision of damaged DNA segments through the NER process. It also contributes to the transcription initiation process by unwinding DNA and permitting the RNA polymerase to access the DNA template. These roles are critical for cellular processes like replication and transcription which require accurate and clean DNA templates.
Pathways
TTDA is important in the nucleotide excision repair and transcription initiation pathways. Within the NER pathway TTDA works alongside other TFIIH complex members such as XPB and XPD which helicases that help unwind DNA. In transcription initiation TTDA is related to the functioning of RNA polymerase II ensuring successful transcription starts. The interconnection of TTDA with these processes highlights its contribution to cellular health and replication fidelity.
Specifications
Form
Liquid
General info
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.
Sequence similarities
Belongs to the TFB5 family.
Subcellular localisation
Nucleus
Target data
Product promise
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