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AB159756

Recombinant Human TTPA/TPP1 protein

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Recombinant Human TTPA/TPP1 protein is a Human Full Length protein, in the 1 to 278 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

TPP1, TTPA, Alpha-tocopherol transfer protein, Alpha-TTP

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SDS-PAGE - Recombinant Human TTPA/TPP1 protein (AB159756)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TTPA/TPP1 protein (AB159756)

ab159756 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P49638

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as TTPA.
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Sequence info

[{"sequence":"MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEISADLHPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIAHWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFPDILPLEYGGEEFSMEDICQEWTNFIMKSEDYLSSISESIQ","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":278,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P49638","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TTPA also known as tocopherol (alpha) transfer protein and TPP1 is a protein with a mass of approximately 32 kDa. The protein binds to alpha-tocopherol a type of vitamin E and facilitates its transfer to cellular membranes. TTPA is mainly expressed in the liver but also found in smaller amounts in the brain lungs and other tissues. The protein ensures the efficient distribution of vitamin E throughout the body playing a significant role in maintaining cellular health.
Biological function summary

In many organisms TTPA acts as an important transporter of vitamin E helping protect cells against oxidative damage by delivering it to sites where it acts as an antioxidant. While not formally part of a recognized complex the protein interacts with cellular membranes as it transfers alpha-tocopherol. The function supports cell protection and injury prevention by ensuring an adequate supply of this essential vitamin.

Pathways

Vitamin E's movement within the body is directly influenced by TTPA's activity placing the protein within the tocopherol transport and metabolism pathways. The interaction with other antioxidant systems like the glutathione pathway highlights TTPA's importance in cellular redox homeostasis. TTPA-related proteins such as vitamin E-binding proteins modulate this transport and influence overall oxidative stress responses.

Mutations in the TTPA gene can lead to a rare neurodegenerative disorder known as ataxia with vitamin E deficiency (AVED). This condition highlights the critical need for functional TTPA in neurological health. Additionally research has linked TTPA to liver-related conditions where an association is found with lower levels of vitamin E and liver damage emphasizing its role as a protector of liver tissues. Understanding these connections helps target TTPA-related pathways and proteins such as APOB for potential therapeutic interventions.
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Specifications

Form

Liquid

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General info

Function

Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed : 7887897). Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity).

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Product protocols

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Target data

Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed : 7887897). Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity).
See full target information TTPA
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Complementary Products

Primary Antibodies

AB155323

Anti-TTPA/TPP1 antibody

Western blot - Anti-TTPA/TPP1 antibody (AB155323)

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