Recombinant Human TUBA1C protein is a Human Full Length protein, in the 1 to 449 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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- Scientific reports 12:105682022SILAC kinase screen identifies potential MASTL substrates.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKamila A Marzec,Samuel Rogers,Rachael McCloy,Benjamin L Parker,David E James,D Neil Watkins,Andrew BurgessPubMed 35732702
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M R E C I S I H V G Q A G V Q I G N A C W E L Y C L E H G I Q P D G Q M P S D K T I G G G D D S F N T F F S E T G A G K H V P R A V F V D L E P T V I D E V R T G T Y R Q L F H P E Q L I T G K E D A A N N Y A R G H Y T I G K E I I D L V L D R I R K L A D Q C T G L Q G F L V F H S F G G G T G S G F T S L L M E R L S V D Y G K K S K L E F S I Y P A P Q V S T A V V E P Y N S I L T T H T T L E H S D C A F M V D N E A I Y D I C R R N L D I E R P T Y T N L N R L I S Q I V S S I T A S L R F D G A L N V D L T E F Q T N L V P Y P R I H F P L A T Y A P V I S A E K A Y H E Q L T V A E I T N A C F E P A N Q M V K C D P R H G K Y M A C C L L Y R G D V V P K D V N A A I A T I K T K R T I Q F V D W C P T G F K V G I N Y Q P P T V V P G G D L A K V Q R A V C M L S N T T A V A E A W A R L D H K F D L M Y A K R A F V H W Y V G E G M E E G E F S E A R E D M A A L E K D Y E E V G A D S A D G E D E G E E Y
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Alternative names
TUBA6, TUBA1C, Tubulin alpha-1C chain, Alpha-tubulin 6, Tubulin alpha-6 chain
Recommended products
Recombinant Human TUBA1C protein is a Human Full Length protein, in the 1 to 449 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9BQE3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M R E C I S I H V G Q A G V Q I G N A C W E L Y C L E H G I Q P D G Q M P S D K T I G G G D D S F N T F F S E T G A G K H V P R A V F V D L E P T V I D E V R T G T Y R Q L F H P E Q L I T G K E D A A N N Y A R G H Y T I G K E I I D L V L D R I R K L A D Q C T G L Q G F L V F H S F G G G T G S G F T S L L M E R L S V D Y G K K S K L E F S I Y P A P Q V S T A V V E P Y N S I L T T H T T L E H S D C A F M V D N E A I Y D I C R R N L D I E R P T Y T N L N R L I S Q I V S S I T A S L R F D G A L N V D L T E F Q T N L V P Y P R I H F P L A T Y A P V I S A E K A Y H E Q L T V A E I T N A C F E P A N Q M V K C D P R H G K Y M A C C L L Y R G D V V P K D V N A A I A T I K T K R T I Q F V D W C P T G F K V G I N Y Q P P T V V P G G D L A K V Q R A V C M L S N T T A V A E A W A R L D H K F D L M Y A K R A F V H W Y V G E G M E E G E F S E A R E D M A A L E K D Y E E V G A D S A D G E D E G E E Y
- Accession
- Q9BQE3
- Protein length
- Full Length
- Amino acids
- 1 to 449
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
- Sequence similarities
Belongs to the tubulin family.
- Post-translational modifications
Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Glutamylation is also involved in cilia motility (By similarity).
- Subcellular localisation
- Cytoskeleton
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TUBA1C also known as tubulin alpha-1C chain is a protein that functions as a component of microtubules which are integral parts of the cytoskeleton in eukaryotic cells. TUBA1C has a molecular mass of approximately 50 kDa. These proteins polymerize to form microtubules essential for various cellular processes such as axonal growth cell division and intracellular transport. TUBA1C is mainly expressed in brain tissues but can also be found in other organ systems indicating its role beyond neuronal function.
- Biological function summary
The tubulin alpha-1C chain plays a significant role in stabilizing cellular structures and facilitating cell division by forming the mitotic spindle. It participates in forming a heterodimer with beta-tubulin a basic structural unit of microtubules. This heterodimer assembles into microtubule filaments which are critical for cell shape and transport mechanisms. TUBA1C as part of the microtubule network helps guide the signaling pathways that are important for neuron functionality and brain development.
- Pathways
TUBA1C is an important player in the mitotic cell cycle and the intracellular transport pathway. It works closely with beta-tubulin to regulate the assembly and disassembly of microtubules which are important steps in cell division and transport within cells. Additionally TUBA1C interacts with MAPs (microtubule-associated proteins) which regulate the dynamics of microtubule systems impacting how cells react to environmental changes and signaling cues during the cell cycle.
- Associated diseases and disorders
Aberrant expression or dysfunction of TUBA1C has been linked to neurodevelopmental disorders and certain types of cancer. Disruption in TUBA1C function can lead to improper neuron migration resulting in conditions such as lissencephaly. Its involvement in cancer relates to its critical role in cell division where abnormal activity can contribute to uncontrolled proliferation. TUBA1C is often examined together with MAPs and other tubulin isoforms in studies related to these diseases to better understand their complex interactions and develop potential therapeutic interventions.
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1 product image
SDS-PAGE - Recombinant Human TUBA1C protein (ab164660)
ab164660 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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