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AB163458

Recombinant Human Tubby like protein 4 (GST tag N-Terminus)

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Recombinant Human Tubby like protein 4 (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 678 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA1397, TUBL4, TUSP, TULP4, Tubby-related protein 4, Tubby superfamily protein, Tubby-like protein 4

1 Images
SDS-PAGE - Recombinant Human Tubby like protein 4 (GST tag N-Terminus) (AB163458)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Tubby like protein 4 (GST tag N-Terminus) (AB163458)

ab163458 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q9NRJ4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGVLGMSWNYPIFLVEDSSESDTDSDDYAPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNNYDDLSPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLGELPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIISICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVSKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDDPEVGGPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKPDEIYGNSLISTVIDSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRISIEARKSPKLPRAAQELSRSPRLPLRKPSVGSPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPRQMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPGDAVWTD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":678,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":null,"tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tubby like protein 4 (TULP4) also known by its alternate name TULP4 is a member of the tubby family of proteins. It has a molecular mass of approximately 62 kDa. TULP4 is expressed in several tissues but has notable expression in the brain and retinal tissues. Its structure includes a conserved C-terminal tubby domain which is likely involved in DNA binding alongside more variable N-terminal segments which differentiate it from other tubby-like proteins.
Biological function summary

Tubby-like proteins are involved in various cellular processes such as signal transduction and transcriptional regulation. TULP4 does not act in isolation; it forms part of protein complexes which interact with cell membranes and cytoskeletal components for carrying out its functions. These interactions help mediate intracellular signaling pathways that are essential for maintaining cellular homeostasis and function.

Pathways

Tubby like protein 4 participates in signaling and metabolic pathways most notably the Phosphatidylinositol 45-bisphosphate and PI3K/AKT pathways. Within these pathways TULP4 interacts with proteins like phosphoinositide which plays a role in modulating signal transduction. These pathways are essential for cell growth survival and metabolism and help in understanding how TULP4 regulates these biological processes.

Mutations and dysfunctions in tubby like protein 4 are associated with retinal degeneration and obesity-related conditions. Retinitis pigmentosa a disorder connected to retinal degeneration links TULP4's role within the retina to visual impairment. Similarly the protein may have ties with other proteins such as TUB and TULP1 which also relate to obesity pathways. Understanding TULP4's role in these conditions may offer insights into their underlying mechanisms and potential therapeutic targets.
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Specifications

Form

Liquid

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General info

Function

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Sequence similarities

Belongs to the TUB family.

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Product protocols

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Target data

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
See full target information TULP4
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