Recombinant Human Tubby like protein 4 is a Human Full Length protein, in the 1 to 678 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M Y A A V E H G P V L C S D S N I L C L S W K G R V P K S E K E K P V C R R R Y Y E E G W L A T G N G R G V V G V T F T S S H C R R D R S T P Q R I N F N L R G H N S E V V L V R W N E P Y Q K L A T C D A D G G I F V W I Q Y E G R W S V E L V N D R G A Q V S D F T W S H D G T Q A L I S Y R D G F V L V G S V S G Q R H W S S E I N L E S Q I T C G I W T P D D Q Q V L F G T A D G Q V I V M D C H G R M L A H V L L H E S D G V L G M S W N Y P I F L V E D S S E S D T D S D D Y A P P Q D G P A A Y P I P V Q N I K P L L T V S F T S G D I S L M N N Y D D L S P T V I R S G L K E V V A Q W C T Q G D L L A V A G M E R Q T Q L G E L P N G P L L K S A M V K F Y N V R G E H I F T L D T L V Q R P I I S I C W G H R D S R L L M A S G P A L Y V V R V E H R V S S L Q L L C Q Q A I A S T L R E D K D V S K L T L P P R L C S Y L S T A F I P T I K P P I P D P N N M R D F V S Y P S A G N E R L H C T M K R T E D D P E V G G P C Y T L Y L E Y L G G L V P I L K G R R I S K L R P E F V I M D P R T D S K P D E I Y G N S L I S T V I D S C N C S D S S D I E L S D D W A A K K S P K I S R A S K S P K L P R I S I E A R K S P K L P R A A Q E L S R S P R L P L R K P S V G S P S L T R R E F P F E D I T Q H N Y L A Q V T S N I W G T K F K I V G L A A F L P T N L G A V I Y K T S L L H L Q P R Q M T I Y L P E V R K I S M D Y I N L P V F N P N V F S E D E D D L P G D A V W T D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alternative names
KIAA1397, TUBL4, TUSP, TULP4, Tubby-related protein 4, Tubby superfamily protein, Tubby-like protein 4
Recommended products
Recombinant Human Tubby like protein 4 is a Human Full Length protein, in the 1 to 678 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9NRJ4-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M Y A A V E H G P V L C S D S N I L C L S W K G R V P K S E K E K P V C R R R Y Y E E G W L A T G N G R G V V G V T F T S S H C R R D R S T P Q R I N F N L R G H N S E V V L V R W N E P Y Q K L A T C D A D G G I F V W I Q Y E G R W S V E L V N D R G A Q V S D F T W S H D G T Q A L I S Y R D G F V L V G S V S G Q R H W S S E I N L E S Q I T C G I W T P D D Q Q V L F G T A D G Q V I V M D C H G R M L A H V L L H E S D G V L G M S W N Y P I F L V E D S S E S D T D S D D Y A P P Q D G P A A Y P I P V Q N I K P L L T V S F T S G D I S L M N N Y D D L S P T V I R S G L K E V V A Q W C T Q G D L L A V A G M E R Q T Q L G E L P N G P L L K S A M V K F Y N V R G E H I F T L D T L V Q R P I I S I C W G H R D S R L L M A S G P A L Y V V R V E H R V S S L Q L L C Q Q A I A S T L R E D K D V S K L T L P P R L C S Y L S T A F I P T I K P P I P D P N N M R D F V S Y P S A G N E R L H C T M K R T E D D P E V G G P C Y T L Y L E Y L G G L V P I L K G R R I S K L R P E F V I M D P R T D S K P D E I Y G N S L I S T V I D S C N C S D S S D I E L S D D W A A K K S P K I S R A S K S P K L P R I S I E A R K S P K L P R A A Q E L S R S P R L P L R K P S V G S P S L T R R E F P F E D I T Q H N Y L A Q V T S N I W G T K F K I V G L A A F L P T N L G A V I Y K T S L L H L Q P R Q M T I Y L P E V R K I S M D Y I N L P V F N P N V F S E D E D D L P G D A V W T D
- Protein length
- Full Length
- Amino acids
- 1 to 678
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
- Sequence similarities
Belongs to the TUB family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Tubby like protein 4 (TULP4) also known by its alternate name TULP4 is a member of the tubby family of proteins. It has a molecular mass of approximately 62 kDa. TULP4 is expressed in several tissues but has notable expression in the brain and retinal tissues. Its structure includes a conserved C-terminal tubby domain which is likely involved in DNA binding alongside more variable N-terminal segments which differentiate it from other tubby-like proteins.
- Biological function summary
Tubby-like proteins are involved in various cellular processes such as signal transduction and transcriptional regulation. TULP4 does not act in isolation; it forms part of protein complexes which interact with cell membranes and cytoskeletal components for carrying out its functions. These interactions help mediate intracellular signaling pathways that are essential for maintaining cellular homeostasis and function.
- Pathways
Tubby like protein 4 participates in signaling and metabolic pathways most notably the Phosphatidylinositol 45-bisphosphate and PI3K/AKT pathways. Within these pathways TULP4 interacts with proteins like phosphoinositide which plays a role in modulating signal transduction. These pathways are essential for cell growth survival and metabolism and help in understanding how TULP4 regulates these biological processes.
- Associated diseases and disorders
Mutations and dysfunctions in tubby like protein 4 are associated with retinal degeneration and obesity-related conditions. Retinitis pigmentosa a disorder connected to retinal degeneration links TULP4's role within the retina to visual impairment. Similarly the protein may have ties with other proteins such as TUB and TULP1 which also relate to obesity pathways. Understanding TULP4's role in these conditions may offer insights into their underlying mechanisms and potential therapeutic targets.
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1 product image
SDS-PAGE - Recombinant Human Tubby like protein 4 (ab163458)
ab163458 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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