Recombinant Human TUG protein is a Human Full Length protein, in the 1 to 553 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M A A P A G G G G S A V S V L A P N G R R H T V K V T P S T V L L Q V L E D T C R R Q D F N P C E Y D L K F Q R S V L D L S L Q W R F A N L P N N A K L E M V P A S R S R E G P E N M V R I A L Q L D D G S R L Q D S F C S G Q T L W E L L S H F P Q I R E C L Q H P G G A T P V C V Y T R D E V T G E A A L R G T T L Q S L G L T G G S A T I R F V M K C Y D P V G K T P G S L G S S A S A G Q A A A S A P L P L E S G E L S R G D L S R P E D A D T S G P C C E H T Q E K Q S T R A P A A A P F V P F S G G G Q R L G G P P G P T R P L T S S S A K L P K S L S S P G G P S K P K K S K S G Q D P Q Q E Q E Q E R E R D P Q Q E Q E R E R P V D R E P V D R E P V V C H P D L E E R L Q A W P A E L P D E F F E L T V D D V R R R L A Q L K S E R K R L E E A P L V T K A F R E A Q I K E K L E R Y P K V A L R V L F P D R Y V L Q G F F R P S E T V G D L R D F V R S H L G N P E L S F Y L F I T P P K T V L D D H T Q T L F Q A N L F P A A L V H L G A E E P A G V Y L E P G L L E H A I S P S A A D V L V A R Y M S R A A G S P S P L P A P D P A P K S E P A A E E G A L V P P E P I P G T A Q P V K R S L G K V P K W L K L P A S K R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.
Alternative names
ASPL, RCC17, TUG, UBXD9, UBXN9, ASPSCR1, Tether containing UBX domain for GLUT4, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17, UBX domain-containing protein 9
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Recombinant Human TUG protein is a Human Full Length protein, in the 1 to 553 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9BZE9-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M A A P A G G G G S A V S V L A P N G R R H T V K V T P S T V L L Q V L E D T C R R Q D F N P C E Y D L K F Q R S V L D L S L Q W R F A N L P N N A K L E M V P A S R S R E G P E N M V R I A L Q L D D G S R L Q D S F C S G Q T L W E L L S H F P Q I R E C L Q H P G G A T P V C V Y T R D E V T G E A A L R G T T L Q S L G L T G G S A T I R F V M K C Y D P V G K T P G S L G S S A S A G Q A A A S A P L P L E S G E L S R G D L S R P E D A D T S G P C C E H T Q E K Q S T R A P A A A P F V P F S G G G Q R L G G P P G P T R P L T S S S A K L P K S L S S P G G P S K P K K S K S G Q D P Q Q E Q E Q E R E R D P Q Q E Q E R E R P V D R E P V D R E P V V C H P D L E E R L Q A W P A E L P D E F F E L T V D D V R R R L A Q L K S E R K R L E E A P L V T K A F R E A Q I K E K L E R Y P K V A L R V L F P D R Y V L Q G F F R P S E T V G D L R D F V R S H L G N P E L S F Y L F I T P P K T V L D D H T Q T L F Q A N L F P A A L V H L G A E E P A G V Y L E P G L L E H A I S P S A A D V L V A R Y M S R A A G S P S P L P A P D P A P K S E P A A E E G A L V P P E P I P G T A Q P V K R S L G K V P K W L K L P A S K R
- Accession
- Q9BZE9
- Protein length
- Full Length
- Predicted molecular weight
- 62.6 kDa
- Amino acids
- 1 to 553
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab167886 is purified using conventional chromatography techniques.
General info
- Function
Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Tether containing a UBX domain for GLUT4 (TUG) also known as ASPSCR1 is a protein that plays a role in cellular trafficking. TUG weighs approximately 67 kDa. It is predominantly expressed in adipose tissue and muscle. TUG acts as an inhibitor that helps regulate the recycling and translocation of the glucose transporter type 4 (GLUT4) by tethering it in the cytoplasm until stimulated by insulin.
- Biological function summary
TUG regulates glucose homeostasis and energy balance. It forms a complex with GLUT4-containing vesicles controlling their movement to the plasma membrane in response to insulin stimulation. When insulin is present TUG undergoes proteolytic cleavage releasing GLUT4 so that it can facilitate glucose uptake into cells. This regulation of glucose transport is essential in maintaining normal blood glucose levels.
- Pathways
TUG operates within the insulin signaling pathway and glucose transport pathway. By interacting with GLUT4 TUG controls its translocation important for insulin-mediated glucose uptake. Another significant pathway involving TUG is the trafficking of proteins through the Golgi apparatus where TUG might interact with other UBX domain-containing proteins to manage vesicular traffic.
- Associated diseases and disorders
TUG is linked to type 2 diabetes and insulin resistance. Abnormalities in TUG function or expression can disrupt normal GLUT4 trafficking and impair glucose uptake contributing to these metabolic disorders. Furthermore TUG might interact with proteins related to Alzheimer's disease such as those impacting insulin signaling suggesting a potential role in the pathophysiology of neurodegenerative disorders.
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SDS-PAGE - Recombinant Human TUG protein (ab167886)
15% SDS-PAGE analysis of ab167886 (3µg).
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