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AB167886

Recombinant Human TUG protein (His tag N-Terminus)

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Recombinant Human TUG protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 553 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

ASPL, RCC17, TUG, UBXD9, UBXN9, ASPSCR1, Tether containing UBX domain for GLUT4, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17, UBX domain-containing protein 9

1 Images
SDS-PAGE - Recombinant Human TUG protein (His tag N-Terminus) (AB167886)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TUG protein (His tag N-Terminus) (AB167886)

15% SDS-PAGE analysis of ab167886 (3µg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BZE9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAPAGGGGSAVSVLAPNGRRHTVKVTPSTVLLQVLEDTCRRQDFNPCEYDLKFQRSVLDLSLQWRFANLPNNAKLEMVPASRSREGPENMVRIALQLDDGSRLQDSFCSGQTLWELLSHFPQIRECLQHPGGATPVCVYTRDEVTGEAALRGTTLQSLGLTGGSATIRFVMKCYDPVGKTPGSLGSSASAGQAAASAPLPLESGELSRGDLSRPEDADTSGPCCEHTQEKQSTRAPAAAPFVPFSGGGQRLGGPPGPTRPLTSSSAKLPKSLSSPGGPSKPKKSKSGQDPQQEQEQERERDPQQEQERERPVDREPVDREPVVCHPDLEERLQAWPAELPDEFFELTVDDVRRRLAQLKSERKRLEEAPLVTKAFREAQIKEKLERYPKVALRVLFPDRYVLQGFFRPSETVGDLRDFVRSHLGNPELSFYLFITPPKTVLDDHTQTLFQANLFPAALVHLGAEEPAGVYLEPGLLEHAISPSAADVLVARYMSRAAGSPSPLPAPDPAPKSEPAAEEGALVPPEPIPGTAQPVKRSLGKVPKWLKLPASKR","proteinLength":"Full Length","predictedMolecularWeight":"62.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":553,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BZE9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tether containing a UBX domain for GLUT4 (TUG) also known as ASPSCR1 is a protein that plays a role in cellular trafficking. TUG weighs approximately 67 kDa. It is predominantly expressed in adipose tissue and muscle. TUG acts as an inhibitor that helps regulate the recycling and translocation of the glucose transporter type 4 (GLUT4) by tethering it in the cytoplasm until stimulated by insulin.
Biological function summary

TUG regulates glucose homeostasis and energy balance. It forms a complex with GLUT4-containing vesicles controlling their movement to the plasma membrane in response to insulin stimulation. When insulin is present TUG undergoes proteolytic cleavage releasing GLUT4 so that it can facilitate glucose uptake into cells. This regulation of glucose transport is essential in maintaining normal blood glucose levels.

Pathways

TUG operates within the insulin signaling pathway and glucose transport pathway. By interacting with GLUT4 TUG controls its translocation important for insulin-mediated glucose uptake. Another significant pathway involving TUG is the trafficking of proteins through the Golgi apparatus where TUG might interact with other UBX domain-containing proteins to manage vesicular traffic.

TUG is linked to type 2 diabetes and insulin resistance. Abnormalities in TUG function or expression can disrupt normal GLUT4 trafficking and impair glucose uptake contributing to these metabolic disorders. Furthermore TUG might interact with proteins related to Alzheimer's disease such as those impacting insulin signaling suggesting a potential role in the pathophysiology of neurodegenerative disorders.
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Specifications

Form

Liquid

Additional notes

ab167886 is purified using conventional chromatography techniques.

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General info

Function

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.
See full target information ASPSCR1
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