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AB131704

Recombinant Human TULP1 protein (His tag N-Terminus)

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Recombinant Human TULP1 protein (His tag N-Terminus) is a Human Fragment protein, in the 290 to 542 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

TUBL1, TULP1, Tubby-related protein 1, Tubby-like protein 1

1 Images
SDS-PAGE - Recombinant Human TULP1 protein (His tag N-Terminus) (AB131704)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TULP1 protein (His tag N-Terminus) (AB131704)

15% SDS-PAGE showing ab131704 at approximately 31.1 kDa (3µg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O00294

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.08% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.06% EDTA

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE","proteinLength":"Fragment","predictedMolecularWeight":"31.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":542,"aminoAcidStart":290,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O00294","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TULP1 protein also known as TUB-like protein 1 is a 64 kDa protein primarily expressed in retinal tissue. This protein has a significant role in intracellular trafficking pathways. Mechanically TULP1 interacts with other proteins to ensure the proper transport of photoreceptor-specific cargo. This interaction contributes to maintaining cellular function by keeping the photoreceptor cells healthy.
Biological function summary

TULP1 is critical for the photoreceptor cells' viability and functionality. It does not operate as a solitary entity but rather as a part of a larger molecular complex involved in managing the phototransduction pathways. By partnering with various molecules TULP1 mediates the movement and turnover of phototransduction components helping to maintain the cell structure and promote vision stability.

Pathways

TULP1 plays a significant role in the phototransduction and retinoid cycle pathways. Within these pathways TULP1 collaborates with essential proteins like RPGR and rhodopsin. These collaborations help regulate the transport processes necessary for photoreceptor cell homeostasis contributing to normal visual function and preservation of the retina's structural integrity.

TULP1 mutations associate with retinal-related conditions like retinitis pigmentosa and Leber congenital amaurosis. The connection between TULP1 and these disorders stems from disrupted function of TULP1 leading to impaired transport and eventual photoreceptor degeneration. Additionally a lack of functional interaction between TULP1 and other proteins like rhodopsin contributes significantly to retinal cell damage highlighting TULP1's relevance in hereditary retinal diseases.
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Specifications

Form

Liquid

Additional notes

ab131704 is purified using conventional chromatography techniques

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General info

Function

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

Sequence similarities

Belongs to the TUB family.

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Product protocols

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Target data

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
See full target information TULP1
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