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Recombinant Human TUSC2/FUS1 protein (denatured) is a Human Full Length protein, in the 1 to 110 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human TUSC2/FUS1 protein (denatured) (AB171606), expandable thumbnail

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

Biologically active

No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M G A S G S K A R G L W P F A S A A G G G G S E A A G A E Q A L V R P R G R A V P P F V F T R R G S M F Y D E D G D L A H E F Y E E T I V T K N G Q K R A K L R R V H K N L I P Q G I V K L D H P R I H V D F P V I L Y E V

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

Alternative names

Recommended products

Recombinant Human TUSC2/FUS1 protein (denatured) is a Human Full Length protein, in the 1 to 110 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE

Accession
O75896-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M G A S G S K A R G L W P F A S A A G G G G S E A A G A E Q A L V R P R G R A V P P F V F T R R G S M F Y D E D G D L A H E F Y E E T I V T K N G Q K R A K L R R V H K N L I P Q G I V K L D H P R I H V D F P V I L Y E V

Accession

O75896

Protein length

Full Length

Predicted molecular weight

14.5 kDa

Amino acids

1 to 110

Nature

Recombinant

Tags

His tag N-Terminus

Specifications

Form

Liquid

General info

Function

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

Sequence similarities

Belongs to the TUSC2 family.

Post-translational modifications

Myristoylation is required for tumor suppressor activity.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

This product was previously labelled as TUSC2

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The TUSC2/FUS1 protein also known by its alternate name TUSC2 plays an essential role in cellular processes. It has a molecular mass of approximately 12 kDa and is found throughout various tissues but is predominantly expressed in the mitochondria. TUSC2 localizes to chromosomal region 3p21.3 which often undergoes deletions in lung cancer. Its expression can be lost or significantly reduced in certain cancers indicating its potential tumor-suppressive role.

Biological function summary

TUSC2 participates in several critical cellular functions and is part of a larger complex with other proteins. It influences cell proliferation apoptosis and signal transduction pathways. TUSC2 functions as a tumor suppressor helping to regulate cell growth and prevent malignant transformation. It acts in apoptosis induction and cell cycle control often by modulating reactive oxygen species (ROS) levels within cells.

Pathways

TUSC2 is instrumental in regulating several cellular pathways. It is a participant in the PI3K/Akt and MAPK pathways which are vital for cell survival growth and metabolism. TUSC2 interacts with proteins like Akt and p53 playing an important role in maintaining cellular homeostasis and preventing aberrant cell division. These interactions help TUSC2 modulate apoptosis and promote cell-cycle arrest under stressful conditions.

Associated diseases and disorders

TUSC2 has a notable connection to cancer particularly lung cancer and mesothelioma. In these diseases TUSC2 expression often decreases due to chromosomal deletions. The protein's interaction with other tumor suppressors such as p53 and PTEN influences tumorigenesis by disrupting normal signaling pathways leading to uncontrolled cell proliferation. Restoring TUSC2 function or expression could open avenues for therapeutic interventions in cancer treatment.

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1 product image

  • SDS-PAGE - Recombinant Human TUSC2/FUS1 protein (denatured) (ab171606), expandable thumbnail

    SDS-PAGE - Recombinant Human TUSC2/FUS1 protein (denatured) (ab171606)

    SDS-PAGE analysis of ab171606 (3 μg) under reducing conditions and visualized by coomassie blue stain.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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