Recombinant Human TUSC2/FUS1 protein (denatured) is a Human Full Length protein, in the 1 to 110 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
M G S S H H H H H H S S G L V P R G S H M G S M G A S G S K A R G L W P F A S A A G G G G S E A A G A E Q A L V R P R G R A V P P F V F T R R G S M F Y D E D G D L A H E F Y E E T I V T K N G Q K R A K L R R V H K N L I P Q G I V K L D H P R I H V D F P V I L Y E V
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
C3orf11, FUS1, LGCC, PDAP2, C3orf11, TUSC2, FUS1, LGCC, PDAP2, Tumor suppressor candidate 2, Fusion 1 protein, PDGFA-associated protein 2, Fus-1 protein
Recombinant Human TUSC2/FUS1 protein (denatured) is a Human Full Length protein, in the 1 to 110 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
No
Human
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
M G S S H H H H H H S S G L V P R G S H M G S M G A S G S K A R G L W P F A S A A G G G G S E A A G A E Q A L V R P R G R A V P P F V F T R R G S M F Y D E D G D L A H E F Y E E T I V T K N G Q K R A K L R R V H K N L I P Q G I V K L D H P R I H V D F P V I L Y E V
Full Length
14.5 kDa
1 to 110
Recombinant
His tag N-Terminus
Liquid
May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
Belongs to the TUSC2 family.
Myristoylation is required for tumor suppressor activity.
Blue Ice
-20°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product was previously labelled as TUSC2
This supplementary information is collated from multiple sources and compiled automatically.
The TUSC2/FUS1 protein also known by its alternate name TUSC2 plays an essential role in cellular processes. It has a molecular mass of approximately 12 kDa and is found throughout various tissues but is predominantly expressed in the mitochondria. TUSC2 localizes to chromosomal region 3p21.3 which often undergoes deletions in lung cancer. Its expression can be lost or significantly reduced in certain cancers indicating its potential tumor-suppressive role.
TUSC2 participates in several critical cellular functions and is part of a larger complex with other proteins. It influences cell proliferation apoptosis and signal transduction pathways. TUSC2 functions as a tumor suppressor helping to regulate cell growth and prevent malignant transformation. It acts in apoptosis induction and cell cycle control often by modulating reactive oxygen species (ROS) levels within cells.
TUSC2 is instrumental in regulating several cellular pathways. It is a participant in the PI3K/Akt and MAPK pathways which are vital for cell survival growth and metabolism. TUSC2 interacts with proteins like Akt and p53 playing an important role in maintaining cellular homeostasis and preventing aberrant cell division. These interactions help TUSC2 modulate apoptosis and promote cell-cycle arrest under stressful conditions.
TUSC2 has a notable connection to cancer particularly lung cancer and mesothelioma. In these diseases TUSC2 expression often decreases due to chromosomal deletions. The protein's interaction with other tumor suppressors such as p53 and PTEN influences tumorigenesis by disrupting normal signaling pathways leading to uncontrolled cell proliferation. Restoring TUSC2 function or expression could open avenues for therapeutic interventions in cancer treatment.
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SDS-PAGE analysis of ab171606 (3 μg) under reducing conditions and visualized by coomassie blue stain.
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