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Recombinant Human Twist protein is a Human Full Length protein, in the 1 to 202 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Alternative names=Twist-related protein 1, Class A basic helix-loop-helix protein 38, H-twist, bHLHa38, TWIST1, TWIST, BHLHA38
- Expression system
Wheat germ
- Tags
Tag free
- Applications
SDS-PAGE, ELISA, WB
- Biologically active
No
- Sequence
M M Q D V S S S P V S P A D D S L S N S E E E P D R Q Q P P S G K R G G R K R R S S R R S A G G G A G P G G A A G G G V G G G D E P G S P A Q G K R G K K S A G C G G G G G A G G G G G S S S G G G S P Q S Y E E L Q T Q R V M A N V R E R Q R T Q S L N E A F A A L R K I I P T L P S D K L S K I Q T L K L A A R Y I D F L Y Q V L Q S D E L D S K M A S C S Y V A H E R L S Y A F S V W R M E G A W S M S A S H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Images
Target data
Function
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
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Recombinant Human Twist protein is a Human Full Length protein, in the 1 to 202 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Alternative names=Twist-related protein 1, Class A basic helix-loop-helix protein 38, H-twist, bHLHa38, TWIST1, TWIST, BHLHA38
Key facts
- Expression system
Wheat germ
- Tags
Tag free
- Applications
SDS-PAGE, ELISA, WB
- Biologically active
No
- Predicted molecular weight
47.85 kDa
- Amino acids
1 to 202
- Sequence
M M Q D V S S S P V S P A D D S L S N S E E E P D R Q Q P P S G K R G G R K R R S S R R S A G G G A G P G G A A G G G V G G G D E P G S P A Q G K R G K K S A G C G G G G G A G G G G G S S S G G G S P Q S Y E E L Q T Q R V M A N V R E R Q R T Q S L N E A F A A L R K I I P T L P S D K L S K I Q T L K L A A R Y I D F L Y Q V L Q S D E L D S K M A S C S Y V A H E R L S Y A F S V W R M E G A W S M S A S H
- Accession
- Q15672-1
- Protein length
Full Length
- Animal free
No
- Nature
Recombinant
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Specifications
- Form
Liquid
General info
- Function
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
- Subcellular localisation
Nucleus
Storage
- Shipped at conditions
Dry Ice
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
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