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AB103050

Recombinant Human TXNL1 protein (His tag N-Terminus)

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Recombinant Human TXNL1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 289 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

TRP32, TXL, TXNL, TXNL1, Thioredoxin-like protein 1, 32 kDa thioredoxin-related protein

1 Images
SDS-PAGE - Recombinant Human TXNL1 protein (His tag N-Terminus) (AB103050)
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Supplier Data

SDS-PAGE - Recombinant Human TXNL1 protein (His tag N-Terminus) (AB103050)

SDS-PAGE analysis of ab103050

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

O43396

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH","proteinLength":"Full Length","predictedMolecularWeight":"34.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":289,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O43396","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein TXNL1 also known as thioredoxin-like-1 functions mechanically as a member of the thioredoxin family. It contains an active site with a redox-active disulfide bond which allows it to facilitate electron transfer reactions. TXNL1 has a molecular mass of approximately 32 kDa. This protein is expressed in various tissues with distinctive presence in the heart skeletal muscles and liver.
Biological function summary

TXNL1 plays a role in maintaining cellular redox homeostasis and regulates the oxidative stress response. It participates in the thioredoxin complex working alongside other thioredoxin family members to reduce oxidized proteins within cells. By restoring proteins to their functional state TXNL1 helps ensure proper cellular function and protects against damage from reactive oxygen species.

Pathways

The involvement of TXNL1 extends to key cellular signaling pathways including the Nrf2-mediated antioxidant pathway and the MAPK pathway. In the Nrf2 pathway TXNL1 impacts the regulation of antioxidant response elements supporting cell survival under stress conditions. Within the MAPK pathway it interacts with signaling proteins such as JNK modulating stress responses and apoptosis.

TXNL1 shows a connection to conditions like cardiovascular disease and neurodegenerative disorders. Its role in oxidative stress makes it relevant in cardiovascular disease where imbalance in redox homeostasis contributes to disease progression. In neurodegenerative disorders interactions of TXNL1 with proteins such as Nrf2 play part in modulating neuronal survival and apoptosis highlighting its potential influence on disease mechanisms.
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Specifications

Form

Liquid

Additional notes

ab103050 was purified using conventional chromatography techniques.

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General info

Function

Active thioredoxin with a redox potential of about -250 mV.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Active thioredoxin with a redox potential of about -250 mV.
See full target information TXNL1
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