Recombinant Human TXNL1 protein is a Human Full Length protein, in the 1 to 289 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M V G V K P V G S D P D F Q P E L S G A G S R L A V V K F T M R G C G P C L R I A P A F S S M S N K Y P Q A V F L E V D V H Q C Q G T A A T N N I S A T P T F L F F R N K V R I D Q Y Q G A D A V G L E E K I K Q H L E N D P G S N E D T D I P K G Y M D L M P F I N K A G C E C L N E S D E H G F D N C L R K D T T F L E S D C D E Q L L I T V A F N Q P V K L Y S M K F Q G P D N G Q G P K Y V K I F I N L P R S M D F E E A E R S E P T Q A L E L T E D D I K E D G I V P L R Y V K F Q N V N S V T I F V Q S N Q G E E E T T R I S Y F T F I G T P V Q A T N M N D F K R V V G K K G E S H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Active thioredoxin with a redox potential of about -250 mV.
Alternative names
TRP32, TXL, TXNL, TXNL1, Thioredoxin-like protein 1, 32 kDa thioredoxin-related protein
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Recombinant Human TXNL1 protein is a Human Full Length protein, in the 1 to 289 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- O43396-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M V G V K P V G S D P D F Q P E L S G A G S R L A V V K F T M R G C G P C L R I A P A F S S M S N K Y P Q A V F L E V D V H Q C Q G T A A T N N I S A T P T F L F F R N K V R I D Q Y Q G A D A V G L E E K I K Q H L E N D P G S N E D T D I P K G Y M D L M P F I N K A G C E C L N E S D E H G F D N C L R K D T T F L E S D C D E Q L L I T V A F N Q P V K L Y S M K F Q G P D N G Q G P K Y V K I F I N L P R S M D F E E A E R S E P T Q A L E L T E D D I K E D G I V P L R Y V K F Q N V N S V T I F V Q S N Q G E E E T T R I S Y F T F I G T P V Q A T N M N D F K R V V G K K G E S H
- Accession
- O43396
- Protein length
- Full Length
- Predicted molecular weight
- 34.4 kDa
- Amino acids
- 1 to 289
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab103050 was purified using conventional chromatography techniques.
General info
- Function
Active thioredoxin with a redox potential of about -250 mV.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein TXNL1 also known as thioredoxin-like-1 functions mechanically as a member of the thioredoxin family. It contains an active site with a redox-active disulfide bond which allows it to facilitate electron transfer reactions. TXNL1 has a molecular mass of approximately 32 kDa. This protein is expressed in various tissues with distinctive presence in the heart skeletal muscles and liver.
- Biological function summary
TXNL1 plays a role in maintaining cellular redox homeostasis and regulates the oxidative stress response. It participates in the thioredoxin complex working alongside other thioredoxin family members to reduce oxidized proteins within cells. By restoring proteins to their functional state TXNL1 helps ensure proper cellular function and protects against damage from reactive oxygen species.
- Pathways
The involvement of TXNL1 extends to key cellular signaling pathways including the Nrf2-mediated antioxidant pathway and the MAPK pathway. In the Nrf2 pathway TXNL1 impacts the regulation of antioxidant response elements supporting cell survival under stress conditions. Within the MAPK pathway it interacts with signaling proteins such as JNK modulating stress responses and apoptosis.
- Associated diseases and disorders
TXNL1 shows a connection to conditions like cardiovascular disease and neurodegenerative disorders. Its role in oxidative stress makes it relevant in cardiovascular disease where imbalance in redox homeostasis contributes to disease progression. In neurodegenerative disorders interactions of TXNL1 with proteins such as Nrf2 play part in modulating neuronal survival and apoptosis highlighting its potential influence on disease mechanisms.
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SDS-PAGE - Recombinant Human TXNL1 protein (ab103050)
SDS-PAGE analysis of ab103050
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