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AB126672

Recombinant Human TXNL4A protein

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Recombinant Human TXNL4A protein is a Human Full Length protein, in the 1 to 142 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

DIM1, TXNL4, TXNL4A, Thioredoxin-like protein 4A, DIM1 protein homolog, Spliceosomal U5 snRNP-specific 15 kDa protein, Thioredoxin-like U5 snRNP protein U5-15kD

1 Images
SDS-PAGE - Recombinant Human TXNL4A protein (AB126672)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human TXNL4A protein (AB126672)

15% SDS-PAGE analysis of 3µg ab126672.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P83876

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY","proteinLength":"Full Length","predictedMolecularWeight":"19.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":142,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P83876","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TXNL4A also known as thioredoxin-like 4A or Dim2 is a 16 kDa protein involved in RNA splicing. It is widely expressed in various tissues including lung and muscle tissue. This protein belongs to the thioredoxin superfamily which contains small proteins with redox activity notable for their catalytic cycle involving thiol-disulfide exchange. TXNL4A acts as an essential factor in pre-mRNA splicing which is an important step in gene expression.
Biological function summary

TXNL4A functions as part of the survival of motor neuron (SMN) complex which is responsible for the assembly of small nuclear ribonucleoproteins (snRNPs). SnRNPs are fundamental components of the spliceosome the molecular machine that performs pre-mRNA splicing. TXNL4A contributes to the synthesis of spliceosomal snRNPs influencing gene expression regulations. It interacts with several specific proteins within the SMN complex to ensure proper snRNP assembly and maturation.

Pathways

TXNL4A plays an important role in the spliceosome pathway and the mRNA processing pathway. Its interactions in the spliceosome pathway are important for the regulation of alternative splicing which greatly expands protein diversity. TXNL4A interacts with other proteins such as SMN1 and Gemin2 within this pathway coordinating the assembly of snRNPs. In the mRNA processing pathway the accurate execution of pre-mRNA splicing affects downstream physiological processes.

TXNL4A has implications in spinal muscular atrophy (SMA) where there is a deficiency of SMN1. The protein's role in snRNP assembly ties it to the pathogenesis of SMA which affects motor neurons leading to muscle wasting and weakness. Changes in TXNL4A expression or function might link to myelodysplastic syndromes where dysregulated RNA processing occurs. This connection suggests TXNL4A's potential as a therapeutic target in these diseases.
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Specifications

Form

Liquid

Additional notes

ab126672 is purified using conventional chromatography techniques.

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General info

Function

Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

Sequence similarities

Belongs to the DIM1 family.

Post-translational modifications

The disulfide bond seen in structures determined by X-ray crystallography (PubMed:10610776) and NMR (PubMed:12911302) is not essential for protein folding and function (PubMed:12911302, PubMed:17467737).

Subcellular localisation

Nucleus

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Product protocols

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Target data

Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
See full target information TXNL4A
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