Recombinant Human Uba6 protein (GST tag N-Terminus)
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Recombinant Human Uba6 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 389 aa range, expressed in Wheat germ, with >80%, suitable for ELISA, WB.
View Alternative Names
MOP4, UBE1L2, UBA6, Ubiquitin-like modifier-activating enzyme 6, Ubiquitin-activating enzyme 6, Monocyte protein 4, Ubiquitin-activating enzyme E1-like protein 2, MOP-4, E1-L2
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Uba6 protein (GST tag N-Terminus) (AB163029)
ab163029 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Uba6 modifies proteins by attaching ubiquitin moieties which tags them for various fates including degradation or location changes. Uba6 functions as a part of the ubiquitin-proteasome system (UPS) a critical protein degradation and quality control pathway. In this system Uba6 collaborates with E2 conjugating enzymes such as Ube2z which transfer ubiquitin from Uba6 to substrate proteins. This involvement emphasizes its role in protein homeostasis and cellular stress responses by controlling protein stability.
Pathways
Uba6 takes part in the maintenance of protein homeostasis and also influences the NEDD8 modification pathway. The UPS pathway integrates Uba6 with processes involving protein turnover and stress responses maintaining cellular oxidative stress levels. In the NEDD8 pathway Uba6 interacts with proteins like UBE2D which influence protein degradation scenarios that differ from those managed by the classic ubiquitin system. These pathways highlight the diverse regulatory roles Uba6 holds in managing intracellular protein dynamics.
Specifications
Form
Liquid
Additional notes
Glutathione Sepharose
General info
Function
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
Sequence similarities
Belongs to the ubiquitin-activating E1 family.
Target data
Product promise
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