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AB162684

Recombinant Human UBASH3A protein (GST tag N-Terminus)

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Recombinant Human UBASH3A protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 451 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

STS2, UBASH3A, Ubiquitin-associated and SH3 domain-containing protein A, Cbl-interacting protein 4, Suppressor of T-cell receptor signaling 2, T-cell ubiquitin ligand 1, CLIP4, STS-2, TULA-1

1 Images
SDS-PAGE - Recombinant Human UBASH3A protein (GST tag N-Terminus) (AB162684)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human UBASH3A protein (GST tag N-Terminus) (AB162684)

ab162684 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

P57075

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB197168

Anti-UBASH3A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBASH3A antibody (AB197168)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

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Proteins & Peptides

AB161146

Recombinant Human BS69 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BS69 protein (GST tag N-Terminus) (AB161146)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAAGETQLYAKVSNKLKGRSSPSLLEPLLAMGFPVHTALKALAATGRKTAEEALAWLHDHCNDPSLDDPIPQEYALFLCPTGPLLEKLQEFWRESKRQCAKNRAHEVFPHVTLCDFFTCEDQKVECLYEALKRAGDRLLGSFPTAVPLALHSSISYLGFFVSGSPADVIREFAMTFATEASLLADCSVKPCTKQLHLTLAHKFYPHHQRTLEQLARAIPLGHSCQWTAALYSRDMRFVHYQTLRALFQYKPQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFLPENYTDRASESDTWVKHRMYTFSLATDLNSRKDGEASSRCSGEFLPQTARSLSSLQALQATVARKSVLVVRHGERVDQIFGKAWLQQCSTPDGNYYRPDLNFPCSLPRRSRGIKDFENDPPLSSCGIFQSRIAGMFEDCLVGKVTITATLIMASRHPA","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":451,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P57075","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UBASH3A also known as suppressor of T-cell receptor signaling 1 (STS-1) is a protein involved in regulating T-cell signaling. It has a molecular mass of approximately 67 kDa. UBASH3A is expressed mainly in lymphoid tissues including the thymus and spleen. The protein contains a Src homology 3 (SH3) domain and a ubiquitin-associated (UBA) domain which are important for its interactions with other proteins and its function in cellular signaling processes.
Biological function summary

UBASH3A plays an important role in modulating immune responses. It regulates T-cell receptor (TCR) signaling by acting as a negative regulator ensuring proper immune tolerance and preventing overstimulation of immune responses. UBASH3A is not known to be part of a larger protein complex. It interacts with signaling molecules and adaptor proteins to modulate signal transduction pathways in T-cells controlling their activation and proliferation.

Pathways

UBASH3A influences T-cell signaling pathways and the broader immune response. It is involved in the TCR signaling pathway which is essential for the activation and development of T-cells. Through this pathway UBASH3A interacts with proteins like LCK and ZAP-70 which are necessary for TCR-induced signaling events leading to cytokine production and cell-mediated immune responses. Additionally UBASH3A is connected to pathways controlling apoptosis where it fine-tunes the balance between cell survival and programmed cell death.

UBASH3A has implications in autoimmune diseases and cancer. Its role as a negative regulator of TCR signaling links it to autoimmune conditions such as type 1 diabetes where improper TCR signaling can lead to autoimmune attack of pancreatic beta cells. Furthermore altered expression or function of UBASH3A can impact cancer progression particularly in hematological cancers like leukemia where T-cell signaling dysregulation can promote proliferation. Proteins such as CTLA-4 and PD-1 which are involved in immune checkpoint pathways can be indirectly influenced by UBASH3A activity affecting disease progression and treatment outcomes.
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Specifications

Form

Liquid

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General info

Function

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

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Product protocols

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Target data

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
See full target information UBASH3A
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