Recombinant human Ube2L6 protein (Active)
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Recombinant human Ube2L6 protein (Active) is a Human Full Length protein, in the 1 to 153 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, FuncS.
View Alternative Names
UBCH8, UBE2L6, Ubiquitin/ISG15-conjugating enzyme E2 L6, E2 ubiquitin-conjugating enzyme L6, Retinoic acid-induced gene B protein, UbcH8, Ubiquitin carrier protein L6, Ubiquitin-protein ligase L6, RIG-B
- FuncS
Supplier Data
Functional Studies - Recombinant human Ube2L6 protein (Active) (AB269106)
Protein activity of ab269106 was determined to be 13 nmol/min/mg in an ubiquitination assay using human ISG15 protein substrate.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant human Ube2L6 protein (Active) (AB269106)
SDS-PAGE analysis of ab269106.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Ube2L6 contributes to protein quality control within the cell. The enzyme participates in the post-translational modification of proteins specifically tagging misfolded or damaged proteins with ubiquitin for degradation. It interacts with several E3 ligases and forms part of the larger ubiquitin-proteasome complex. This function helps maintain protein homeostasis.
Pathways
Ube2L6 plays a role in both the NF-kB signaling and type I interferon pathways. In the NF-kB signaling pathway it facilitates the degradation of inhibitory proteins allowing nuclear translocation of NF-kB and subsequent gene expression. It associates with proteins such as TRAF6 which is important for the activation of NF-kB. In type I interferon signaling Ube2L6 aids in the antiviral response by assisting in the modification of target proteins enhancing the immune defense.
Specifications
Form
Liquid
General info
Function
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
Sequence similarities
Belongs to the ubiquitin-conjugating enzyme family.
Post-translational modifications
ISGylated.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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