Recombinant Human UBE2Z protein
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Recombinant Human UBE2Z protein is a Human Fragment protein, in the 109 to 354 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, WB.
View Alternative Names
HOYS7, UBE2Z, Ubiquitin-conjugating enzyme E2 Z, E2 ubiquitin-conjugating enzyme Z, Uba6-specific E2 conjugating enzyme 1, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z, Use1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human UBE2Z protein (AB167938)
SDS Page analysis of ab167938
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
UBE2Z is involved in protein degradation and regulation of protein homeostasis. It is an important part of the ubiquitin-proteasome system ensuring damaged or misfolded proteins are marked for degradation. UBE2Z can function independently or in conjunction with multi-protein complexes. It has an important role in regulating cellular processes like cell cycle progression DNA repair and response to stress. Additionally it contributes to the regulation of several cellular pathways through these processes.
Pathways
UBE2Z is significantly involved in the protein ubiquitination pathway and cellular response to oxidative stress. In the protein ubiquitination pathway it interacts with various E3 ligases influencing protein turnover. Notably it interacts with the KEAP1 pathway which regulates the degradation of NRF2 a transcription factor involved in antioxidative responses. UBE2Z’s association with these pathways links it to the modulation of protein stability and cellular sensitivity to oxidative damage.
Specifications
Form
Liquid
General info
Function
Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.
Sequence similarities
Belongs to the ubiquitin-conjugating enzyme family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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