Recombinant Human UBL3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UBL3 also known as Ubiquitin-Like Protein 3 is a small protein with a molecular mass of approximately 12 kDa. It is expressed in various tissues but shows high expression in the liver and brain. Mechanically UBL3 contributes to the modification of other proteins through ubiquitin-like processes which means it modifies substrates by attaching itself or similar molecules. This function helps in regulating protein degradation localization and activity within the cell.

Biological function summary

UBL3 participates in membrane trafficking and exosome biogenesis. It often associates with endosomal sorting complexes required for transport (ESCRT). By interacting with this complex UBL3 influences the sorting of proteins into vesicles and their subsequent exocytosis. The activity of UBL3 in this context suggests a significant role in cellular communication and the maintenance of membrane integrity.

Pathways

UBL3 interacts in key cellular processes such as the ESCRT pathway and autophagy. In the ESCRT pathway UBL3 works with proteins like CHMP4B and VPS4 managing cargo selection during endosomal transport. Its involvement in the autophagy pathway indicates a role in cellular homeostasis and stress responses associating with proteins such as LC3. These pathways demonstrate UBL3's impact on protein turnover and cellular response to environmental changes.

UBL3 links to neurodegenerative disorders and liver fibrosis. In neurodegenerative diseases the malfunctioning of exosome biogenesis and endosomal pathways influenced by UBL3 might lead to protein aggregation and neuronal loss. Furthermore in liver fibrosis UBL3-associated pathways might alter cellular stress responses. Connections in these diseases often include proteins like alpha-synuclein for neurodegeneration and transforming growth factor-beta (TGF-β) signaling components in liver fibrosis highlighting UBL3's role in complex disease mechanisms.