Recombinant Human UBL5 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UBL5 also known as Ubiquitin-like protein 5 performs vital functions in cellular mechanisms. This protein has a molecular mass of approximately 14 kDa. It is widely expressed across various tissues indicating a universal role in the cellular environment. Mechanically UBL5 does not conjugate to proteins like other ubiquitin-like proteins but modifies cellular processes through protein-protein interactions. Though not highly abundant its presence in different organisms shows its conserved function across species.

Biological function summary

UBL5 engages in the regulation of important cellular processes such as RNA splicing and mitochondrial function. It participates as a part of multi-protein complexes influencing pre-mRNA splicing by facilitating the assembly of the spliceosome complex. The complex formation helps UBL5 maintain properly sequenced mRNA by eliminating introns. UBL5 also plays a role in the maintenance and functionality of mitochondria ensuring energy production and cellular metabolism remain stable.

Pathways

UBL5 is deeply integrated into RNA processing and mitochondrial maintenance pathways. In RNA processing it aligns with proteins such as SF3B1 and U2AF2 to supervise spliceosome assembly and splicing fidelity. In mitochondrial maintenance UBL5 interconnects with proteins like PGC-1α ensuring efficient mitochondrial biogenesis and energy metabolism. These interactions help UBL5 support pathways that are essential for cellular energy regulation and gene expression.

UBL5's dysregulation associates with conditions like cancer and metabolic syndrome. In some cancers aberrant UBL5 expression disrupts normal RNA splicing contributing to oncogenic transformations. This alteration links UBL5 to proteins like MYC which drive tumorigenesis. In metabolic syndrome UBL5 interacts with malfunctioning mitochondrial pathways and proteins like Nrf2 affecting cellular metabolism and oxidative stress response. This makes UBL5 a potential target for therapeutic interventions aimed at addressing these disorders.