Recombinant Human UBLCP1 protein
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Recombinant Human UBLCP1 protein is a Human Full Length protein, in the 1 to 318 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor UBLCP1, UBLCP1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human UBLCP1 protein (AB202175)
15% SDS-PAGE analysis of ab202175 (3 μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
UBLCP1 plays a significant role in regulating cellular processes by removing phosphate groups from substrates which can affect protein activity cellular localization or interaction with other proteins. It does not work alone but associates with other molecules to form complexes that allow it to control different cellular processes effectively. One such interaction is with the RNA polymerase II where UBLCP1 may regulate transcription by dephosphorylating the C-terminal domain of RNA polymerase II.
Pathways
Several studies have linked UBLCP1 to key signaling pathways that control cell cycle and transcription regulation. It interacts with pathways involving RNA polymerase II influencing its activity during transcription. Additionally UBLCP1 shares interactions with components of the TGF-beta pathway though details of this relationship require further study. This connection could suggest a role in controlling growth and differentiation signals in cells.
Specifications
Form
Liquid
Additional notes
purified by using conventional chromatography techniques.
General info
Function
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity (PubMed : 21949367, PubMed : 28539385). Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1 (PubMed : 28539385). Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly (PubMed : 28539385). Has also been reported to stimulate the proteolytic activity of the 26S proteasome (PubMed : 32071216).
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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