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AB207109

Recombinant Human UBQLN2 protein (His tag N-Terminus)

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Recombinant Human UBQLN2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 624 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

N4BP4, PLIC2, HRIHFB2157, UBQLN2, Ubiquilin-2, Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2, Ubiquitin-like product Chap1/Dsk2, PLIC-2, hPLIC-2

1 Images
SDS-PAGE - Recombinant Human UBQLN2 protein (His tag N-Terminus) (AB207109)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human UBQLN2 protein (His tag N-Terminus) (AB207109)

15% SDS-PAGE analysis of ab207109 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UHD9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAENGESSGPPRPSRGPAAAQGSAAAPAEPKIIKVTVKTPKEKEEFAVPENSSVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQNRPQGQSTQPSNAAGTNTTSASTPRSNSTPISTNSNPFGLGSLGGLAGLSSLGLSSTNFSELQSQMQQQLMASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPMLNAAQEQFGGNPFASVGSSSSSGEGTQPSRTENRDPLPNPWAPPPATQSSATTSTTTSTGSGSGNSSSNATGNTVAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDLAAQMMLNSPLFTANPQLQEQMRPQLPAFLQQMQNPDTLSAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFTPGVGVGVLGTAIGPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPAAPPGSTGSGGPTGPTVSSAAPSETTSPTSESGPNQQFIQQMVQALAGANAPQLPNPEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS","proteinLength":"Full Length","predictedMolecularWeight":"68.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":624,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UHD9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UBQLN2 also known as ubiquitin-like protein UBQLN2 or ubiquilin-2 functions as part of the ubiquitin-proteasome system. It helps in shuttling ubiquitinated proteins to the proteasome for degradation. UBQLN2 has a molecular mass of approximately 66 kDa. Diverse tissues express UBQLN2 including brain kidney and skeletal muscle indicating its widespread importance in various cellular processes.
Biological function summary

UBQLN2 interacts with other proteins involved in protein quality control. It participates in complexes that manage protein homeostasis by assisting in the degradation of misfolded or damaged proteins. This action prevents the accumulation of toxic protein aggregates. UBQLN2's role in the cellular protein degradation pathway highlights its importance in maintaining cellular function and integrity.

Pathways

UBQLN2 engages in the endoplasmic reticulum-associated degradation (ERAD) pathway which ensures the elimination of misfolded proteins from the ER. It also links to the autophagy-lysosome pathway. UBQLN2 interacts with VCP/p97 in these pathways an important protein that assists in extracting ubiquitinated proteins for degradation. Through these interactions UBQLN2 contributes a pivotal role in maintaining cellular homeostasis.

Researchers have linked UBQLN2 mutations to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Abnormalities in UBQLN2 may lead to the accumulation of protein aggregates harmful to neuronal cells. Connections between UBQLN2 and other proteins such as TARDBP (TDP-43) further emphasize its relevance as TDP-43 pathology is common in these neurodegenerative disorders. Understanding UBQLN2's function provides insight into potential therapeutic targets for these diseases.
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Specifications

Form

Liquid

Additional notes

Purified by using conventional chromatography techniques.

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General info

Function

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed : 10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed : 18307982, PubMed : 24215460). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed : 19148225, PubMed : 20529957). Negatively regulates the endocytosis of GPCR receptors : AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed : 18199683).

Post-translational modifications

Degraded during macroautophagy.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed : 10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed : 18307982, PubMed : 24215460). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed : 19148225, PubMed : 20529957). Negatively regulates the endocytosis of GPCR receptors : AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed : 18199683).
See full target information UBQLN2
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